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MMS19 Antibody (PA5-100071) in IHC (P)
Immunohistochemistry analysis of MMS19 in mouse testis tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with MMS19 polyclonal antibody (Product # PA5-100071) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-100071
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human MMS19(Accession Q96T76), corresponding to amino acid residues E342-N392.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2815601
产品详细信息
Antibody detects endogenous levels of total MMS19.
靶标信息
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hMMS19; homolog of yeast MMS19; incisor protein; MET18 homolog; MMS19 cytosolic iron-sulfur assembly component; MMS19 nucleotide excision repair homolog; MMS19 nucleotide excision repair protein homolog; MMS19 nucleotide excision repair-like; MMS19-like (MET18 homolog, S. cerevisiae); MMS19-like protein
基因别名: 2410001K24Rik; 2610042O15Rik; AI316855; C79368; C86341; hMMS19; MET18; MMS19; MMS19L
UniProt ID: (Human) Q96T76, (Mouse) Q9D071
Entrez Gene ID: (Human) 64210, (Rat) 171124, (Mouse) 72199
phosphorelay signal transduction system
DNA metabolic process
DNA repair
nucleotide-excision repair
transcription, DNA-templated
cellular response to DNA damage stimulus
chromosome segregation
response to hormone
iron-sulfur cluster assembly
positive regulation of transcription, DNA-templated
regulation of transcription, DNA-templated
