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产品信息
PA5-51443
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2644021
产品详细信息
Immunogen sequence: LDELESSDLP VALLLAQHKD RSTQLEMQLE KPKPVKPVTF STGIKMGQHI SLAPIHKLEE ALYEYQPLQI ETYGPHVPEL EMLGRLGYLN HVRAASPQDL AG
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 92%.
靶标信息
Progression through the cell cycle requires activation of a series of enzymes designated cyclin dependent kinases (Cdks). The monomeric catalytic subunit, Cdk2, a critical enzyme for initiation of cell cycle progression, is completely inactive. Partial activation is achieved by the binding of regulatory cyclins such as cyclin D1, while full activation requires phosphorylation at Thr 160. The enzyme responsible for phosphorylation of Thr 160 in Cdk2 and also Thr 161 in Cdc2 p34, designated Cdk-activating kinase (CAK), has been partially purified and shown to be comprised of a catalytic subunit, a regulatory subunit and a subunit of unknown function. The regulatory subunit is a novel cyclin (cyclin H) and is required for activation of Cdk7. This previously undescribed protein, now termed Mat1, has been cloned as a protein that associates with the cyclin H-Cdk7 nuclear complex at all stages of the cell cycle. Cyclin H-Cdk7-Mat1 complexes display kinase activity towards Cdk activation domains, and the carboxy terminus of RNA polymerase II. Mat1 appears to constitute the first example of an assembly factor, essential for the formation of an active Cdk-cyclin complex.
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生物信息学
蛋白别名: AdoMet synthetase; AMS1; CDK-activating kinase assembly factor MAT1; CDK7/cyclin-H assembly factor; cyclin G1 interacting protein; Cyclin-G1-interacting protein; EC 2.5.1.6; MAT-I/III; MATA1; Menage a trois; menage a trois 1 (CAK assembly factor); menage a trois homolog 1, cyclin H assembly factor; menage a trois-like protein 1 cyclin H assembly factor; MNAT CDK-activating kinase assembly factor 1; p35; p36; RING finger protein 66; RING finger protein MAT1
基因别名: CAP35; MAT1; MNAT1; RNF66; TFB3
UniProt ID: (Human) P51948
Entrez Gene ID: (Human) 4331
regulation of cyclin-dependent protein serine/threonine kinase activity
G1/S transition of mitotic cell cycle
G2/M transition of mitotic cell cycle
DNA repair
transcription-coupled nucleotide-excision repair
nucleotide-excision repair, preincision complex assembly
regulation of transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase I promoter
transcription elongation from RNA polymerase I promoter
termination of RNA polymerase I transcription
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
7-methylguanosine mRNA capping
protein complex assembly
protein phosphorylation
adult heart development
cell proliferation
ventricular system development
negative regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
positive regulation of smooth muscle cell proliferation
response to calcium ion
