Invitrogen

MOBP Polyclonal Antibody

MOBP Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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MOBP Antibody (PA5-72493) in IHC (P)

Immunohistochemistry analysis of MOBP in formalin-fixed and paraffin-embedded human brain. Samples were incubated with MOBP polyclonal antibody (Product # PA5-72493) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

MOBP Antibody in Immunohistochemistry (IHC)

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产品信息

PA5-72493

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

免疫组化 (IHC)

查看1篇已发表文章 1篇已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:100

流式细胞分析 (Flow)

1:10-1:50

产品规格

种属反应

Human, Mouse

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MOBP

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein A, Antigen affinity chromatography

保存液

PBS, pH 7.4

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2718347

靶标信息

MOBP may play a role in compacting or stabilizing the myelin sheath, possibly by binding the negatively charged acidic phospholipids of the cytoplasmic membrane.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Latent trait modeling of tau neuropathology in progressive supranuclear palsy.

Acta neuropathologica

Kouri N,Murray ME,Reddy JS,Serie DJ,Soto-Beasley A,Allen M,Carrasquillo MM,Wang X,Castanedes MC,Baker MC,Rademakers R,Uitti RJ,Graff-Radford NR,Wszolek ZK,Schellenberg GD,Crook JE,Ertekin-Taner N,Ross OA,Dickson DW

PA5-72493 was used in Immunohistochemistry to investigate the genetic factors underlying progressive supranuclear palsy (PSP), a neurodegenerative disorder characterized by tau neuropathology, revealing significant associations between specific genetic loci (such as MAPT H1c sub-haplotype and MOBP) and various PSP-related tau lesions, providing insights into the biological pathways involved in PSP pathogenesis by affecting regional tau burden.