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产品信息
PA5-96724
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 1-282 of human MORF4L2 (NP_0011358901)
偶联物
形式
Liquid
浓度
0.66 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2808526
产品详细信息
Positive Samples: Cellular Location: Nucleus
Immunogen sequence: MSSRKQGSQP RGQQSAEEEN FKKPTRSNMQ RSKMRGASSG KKTAGPQQKN LEPALPGRWG GRSAENPPSG SVRKTRKNKQ KTPGNGDGGS TSEAPQPPRK KRARADPTVE SEEAFKNRME VKVKIPEELK PWLVEDWDLV TRQKQLFQLP AKKNVDAILE EYANCKKSQG NVDNKEYAVN EVVAGIKEYF NVMLGTQLLY KFERPQYAEI LLAHPDAPMS QVYGAPHLLR LFVRIGAMLA YTPLDEKSLA LLLGYLHDFL KYLAKNSASL FTASDYKVAS AE
靶标信息
MORF4L2 is a protein coding gene. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Liver regeneration-related protein LRRG00119; MORF-related gene X; MORF-related gene X protein; Mortality factor 4-like protein 2; MSL3-2 protein; OTTHUMP00000023756; Protein MSL3-2; RP5-1055C14.2; Sid 393; Transcription factor-like protein MRGX
基因别名: 2410017O14Rik; KIAA0026; LRRG00119; mKIAA0026; MORF4L2; MORFL2; MRGX; Sid393; Sid393p
UniProt ID: (Human) Q15014, (Mouse) Q9R0Q4, (Rat) Q6QI89
Entrez Gene ID: (Human) 9643, (Mouse) 56397, (Rat) 317413
DNA repair
chromatin remodeling
chromatin silencing
transcription, DNA-templated
chromatin modification
histone deacetylation
regulation of growth
histone H4 acetylation
histone H2A acetylation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of striated muscle cell differentiation
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
biological_process
