Invitrogen

MOZ Polyclonal Antibody

MOZ Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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MOZ Antibody (PA5-103467) in IHC (P)

Immunohistochemistry analysis of MOZ in human colorectal cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with MOZ polyclonal antibody (Product # PA5-103467) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.

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产品信息

PA5-103467

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:3,000

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免疫组化（石蜡） (IHC (P))

1:50-1:200

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human KAT6A(Accession Q92794), corresponding to amino acid residues K198-L248.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

AB_2852803

产品详细信息

Antibody detects endogenous levels of total MYST3.

靶标信息

Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

A druggable copper-signalling pathway that drives inflammation.

Nature

Solier S,Müller S,Cañeque T,Versini A,Mansart A,Sindikubwabo F,Baron L,Emam L,Gestraud P,Pantoș GD,Gandon V,Gaillet C,Wu TD,Dingli F,Loew D,Baulande S,Durand S,Sencio V,Robil C,Trottein F,Péricat D,Näser E,Cougoule C,Meunier E,Bègue AL,Salmon H,Manel N,Puisieux A,Watson S,Dawson MA,Servant N,Kroemer G,Annane D,Rodriguez R

PA5-103467 was used in Western Blotting to highlight the central role of copper as a regulator of cell plasticity and unveils a therapeutic strategy based on metabolic reprogramming and the control of epigenetic cell states.

Mon May 01 00:00:00 UTC 2023

The Expression of Histone Acetyltransferase KAT6A in Non-small Cell Lung Cancer.

Anticancer research

Partynska A,Piotrowska A,Pawelczyk K,Rzechonek A,Ratajczak-Wielgomas K,Podhorska-Okolow M,Dziegiel P

PA5-103467 was used in Immunohistochemistry (Paraffin), Western Blot to demonstrate elevated expression of KAT6A in lung cancer cell lines in comparison to normal lung fibroblasts, suggesting its oncogenic role.

Thu Dec 01 00:00:00 UTC 2022

生物信息学

蛋白别名: Histone acetyltransferase KAT6A; histone acetyltransferase MYST3; K(lysine) acetyltransferase 6A; Monocytic leukemia zinc finger homolog; Monocytic leukemia zinc finger protein; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3; MYST histone acetyltransferase (monocytic leukemia) 3; MYST-3; runt-related transcription factor binding protein 2; Runt-related transcription factor-binding protein 2; Zinc finger protein 220

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基因别名: 1500036M03; 9930021N24Rik; KAT6A; MOZ; MRD32; MYST-3; MYST3; RUNXBP2; ZC2HC6A; Zfp220; ZNF220

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UniProt ID: (Human) Q92794, (Rat) Q5TKR9

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Entrez Gene ID: (Human) 7994, (Mouse) 244349, (Rat) 306571

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功能