Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 12
MPP5 Antibody (PA5-99990) in IHC (P)
Immunohistochemistry analysis of MPP5 in human normal tissues adjacent to colorectal cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with MPP5 polyclonal antibody (Product # PA5-99990) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-99990
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human MPP5(Accession Q8N3R9), corresponding to amino acid residues S588-Y638.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2818923
产品详细信息
Antibody detects endogenous levels of total MPP5.
靶标信息
MPP5 (Membrane Protein, Palmitoylated 5) plays a critical role in neurogenesis and hematopoiesis. This protein is crucial for establishing and maintaining cell polarity in epithelial cells and neurons. It is involved in the Par-3 complex, which contributes to maintaining tight junctions in epithelial cells. Mutations in MPP5 have been associated with severe neurologic impairments, including global developmental delay (GDD) and behavioral changes. In animal models, MPP5 is highly involved in the early differentiation of multipotent progenitors and supports long-term lineage-specific contributions, primarily in myeloid and lymphoid cells. MPP5 variants disrupt normal cellular function, leading to profound developmental and functional abnormalities.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: FLJ12615; MAGUK p55 subfamily member 5; membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 5); Membrane protein, palmitoylated 5; membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); palmitoylated 5; protein associated with lin seven 1; Protein associated with Lin-7 1; Protein PALS1; stardust
基因别名: 3830420B02Rik; AI255216; AI644496; MPP5; PALS1
UniProt ID: (Human) Q8N3R9, (Mouse) Q9JLB2, (Rat) B4F7E7
Entrez Gene ID: (Human) 64398, (Mouse) 56217, (Rat) 314259
morphogenesis of an epithelial sheet
peripheral nervous system myelin maintenance
myelin assembly
protein localization to myelin sheath abaxonal region
bicellular tight junction assembly
establishment of protein localization to plasma membrane
establishment of epithelial cell polarity
plasma membrane organization
nucleotide phosphorylation
