Invitrogen

MSH2 Recombinant Mouse Monoclonal Antibody (10G3-R)

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说明书
实验方案
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产品信息

MA5-50645

应用
建议稀释比
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免疫印迹 (WB)

1:2,000-1:5,000
-

免疫组化（石蜡） (IHC (P))

1:200-1:2,000
-

免疫细胞化学 (ICC/IF)

1:200
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Mouse / IgG1

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

10G3-R

抗原

Synthetic peptide within N-terminal residues of Human MSH2 aa 21-70/934.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4, with 0.1% BSA, 40% glycerol

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_3094151

产品详细信息

Positive control: RAW264.7 cell lysate, PC-12 cell lysate, A431 cell lysate, NIH-3T3 cell lysate, mouse testis tissue lysate, mouse heart tissue lysate, Daudi, human colon cancer tissue, human appendix tissue, human breast cancer tissue, human stomach cancer tissue, rat brain tissue, mouse large intestine tissue.

Predicted band size: 105 kDa

Subcellular Location: Nucleus, Chromosome.

靶标信息

Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: DNA mismatch repair protein Msh2; hMSH2; mismatch repair protein; Msh2p; mutS homolog 2, colon cancer, nonpolyposis type 1; MutS protein homolog 2

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基因别名: AI788990; COCA1; FCC1; HNPCC; HNPCC1; LCFS2; MSH2

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UniProt ID: (Human) P43246, (Mouse) P43247, (Rat) P54275

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Entrez Gene ID: (Human) 4436, (Mouse) 17685, (Rat) 81709

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功能
magnesium ion binding four-way junction DNA binding Y-form DNA binding heteroduplex DNA loop binding double-strand/single-strand DNA junction binding DNA binding double-stranded DNA binding single-stranded DNA binding protein binding ATP binding protein C-terminus binding ATPase activity centromeric DNA binding enzyme binding protein kinase binding mismatched DNA binding guanine/thymine mispair binding dinucleotide insertion or deletion binding single guanine insertion binding single thymine insertion binding dinucleotide repeat insertion binding oxidized purine DNA binding MutLalpha complex binding protein homodimerization activity ADP binding nucleotide binding damaged DNA binding DNA-dependent ATPase activity single base insertion or deletion binding DNA metabolism protein
参与通路
meiotic mismatch repair in utero embryonic development oxidative phosphorylation DNA repair mismatch repair postreplication repair double-strand break repair meiotic gene conversion cell cycle arrest reciprocal meiotic recombination germ cell development determination of adult lifespan male gonad development response to X-ray response to UV-B somatic hypermutation of immunoglobulin genes somatic recombination of immunoglobulin gene segments B cell mediated immunity B cell differentiation intra-S DNA damage checkpoint intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of neuron apoptotic process maintenance of DNA repeat elements negative regulation of reciprocal meiotic recombination isotype switching negative regulation of DNA recombination positive regulation of helicase activity somatic recombination of immunoglobulin genes involved in immune response cellular response to DNA damage stimulus cell cycle intrinsic apoptotic signaling pathway in response to DNA damage spermatogenesis response to organic cyclic compound response to drug response to amino acid
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