Invitrogen

MSH2 Recombinant Rabbit Monoclonal Antibody (RM375)

查看其他42个MSH2抗体

抗体检测数据 (2)

MSH2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

MSH2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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MSH2 Antibody (MA5-33073) in IHC (P)

Immunohistochemistry analysis of formalin fixed and paraffin embedded human colon cancer tissue section usingMSH2 Recombinant Monoclonal antibody (Product # MA5-33073) at a dilution of 1:200.

MSH2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

MSH2 Antibody in Western Blot (WB)

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MSH2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry analysis of formalin fixed and paraffin embedded human colon cancer tissue section usingMSH2 Recombinant Monoclonal antibody (Product # MA5-33073) at a dilution of 1:200.

MSH2 Antibody in Western Blot (WB) — Western blot analysis of MSH2 in HeLa lysate, using MSH2 Recombinant Monoclonal antibody (Product # MA5-33073) with a dilution of 1:100.

产品信息

MA5-33073

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:400-1:2,000

-

免疫组化（石蜡） (IHC (P))

1:200-1:1,000

-

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

RM375

抗原

Mammalian cell expressed recombinant protein fragment within 500 amino acids of the N-terminus of human MSH2.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.04 mg/mL

纯化类型

Protein A

保存液

PBS with 1% BSA, 50% glycerol

内含物

0.09% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

AB_2810166

产品详细信息

Specificity: reacts to human DNA mismatch repair protein MSH2.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

靶标信息

Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: DNA mismatch repair protein Msh2; hMSH2; Msh2p; mutS homolog 2, colon cancer, nonpolyposis type 1; MutS protein homolog 2

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基因别名: COCA1; FCC1; HNPCC; HNPCC1; LCFS2; MSH2

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UniProt ID: (Human) P43246

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Entrez Gene ID: (Human) 4436

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magnesium ion binding four-way junction DNA binding Y-form DNA binding heteroduplex DNA loop binding double-strand/single-strand DNA junction binding DNA binding double-stranded DNA binding single-stranded DNA binding protein binding ATP binding protein C-terminus binding ATPase activity centromeric DNA binding enzyme binding protein kinase binding mismatched DNA binding guanine/thymine mispair binding dinucleotide insertion or deletion binding single guanine insertion binding single thymine insertion binding dinucleotide repeat insertion binding oxidized purine DNA binding MutLalpha complex binding protein homodimerization activity ADP binding DNA metabolism protein

meiotic mismatch repair in utero embryonic development oxidative phosphorylation DNA repair mismatch repair postreplication repair double-strand break repair meiotic gene conversion cell cycle arrest reciprocal meiotic recombination germ cell development determination of adult lifespan male gonad development response to X-ray response to UV-B somatic hypermutation of immunoglobulin genes somatic recombination of immunoglobulin gene segments B cell mediated immunity B cell differentiation intra-S DNA damage checkpoint intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of neuron apoptotic process maintenance of DNA repeat elements negative regulation of reciprocal meiotic recombination isotype switching negative regulation of DNA recombination positive regulation of helicase activity