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Recommended positive controls: A549, H1299.
Predicted reactivity: Human (99%), Mouse (83%), Rat (85%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Divergent upstream protein; DNA mismatch repair protein Msh3; DUP; hMSH3; Mismatch repair protein 1; MRP1
基因别名: DUC1; DUG; DUP; MRP1; MSH3
UniProt ID: (Human) P20585
Entrez Gene ID: (Human) 4437