Invitrogen

MSH6 Monoclonal Antibody (44)

产品信息

08-1374

应用

建议稀释比

已发表文章

免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

Assay-dependent

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其他PubMed (Misc)

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产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

抗原

Fusion protein derived from human muscle.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

纯化类型

purified

保存液

PBS, pH 7.4, with 1% BSA

内含物

0.1% sodium azide

保存条件

4° C

运输条件

Ambient (domestic); Wet ice (international)

AB_2532977

靶标信息

The DNA mismatch repair MSH2/MSH6 heterodimer is responsible for the detection of DNA damage, and may promote apoptosis in normal cells, thus protecting mammals from ultraviolet-induced malignant transformation and hence the prevention of skin cancer.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

CD8⁺ tumor-infiltrating lymphocytes within the primary tumor of patients with synchronous de novo metastatic colorectal carcinoma do not track with survival.

Clinical & translational immunology

Millen R,Hendry S,Narasimhan V,Abbott R,Croxford M,Gibbs P,Tie J,Wong HL,Jones I,Kosmider S,Byrne D,Zalcberg J,Fox S,Desai J,Visvanathan K,Ramsay RG,Tran B

08-1374 was used in Immunohistochemistry to explore the prognostic impact of TILs at the primary site in patients who presented de novo with mCRC.

Sat Nov 04 00:00:00 UTC 2023

Lynch syndrome from a surgeon perspective: retrospective study of clinical impact of mismatch repair protein expression analysis in colorectal cancer patients less than 50 years old.

BMC surgery

Baiocchi GL,Portolani N,Vermi W,Baronchelli C,Gheza F,Zogno C,Scaglia A,Marchina E,Tiberio GA,Giulini SM

08-1374 was used in immunohistochemistry - paraffin section to discuss the diagnosis of colorectal cancer and the need for genetic testing for Lynch Syndrome in young patients.

Mon Feb 17 00:00:00 UTC 2014

Renal medullary carcinomas: histopathologic phenotype associated with diverse genotypes.

Human pathology

Gatalica Z,Lilleberg SL,Monzon FA,Koul MS,Bridge JA,Knezetic J,Legendre B,Sharma P,McCue PA

08-1374 was used in immunohistochemistry (paraffin) to examine patients with renal medullary carcinoma with and without sickle cell anemia.

Thu Dec 01 00:00:00 UTC 2011

Clinical and histomolecular endometrial tumor characterization of patients at-risk for Lynch syndrome in South of Brazil.

Familial cancer

Cossio SL,Koehler-Santos P,Pessini SA,Mónego H,Edelweiss MI,Meurer L,Errami A,Coffa J,Bock H,Saraiva-Pereira ML,Ashton-Prolla P,Prolla JC

08-1374 was used in immunohistochemistry - paraffin section to measure the frequency of mismatch repair deficiencies in women diagnosed with endometrial cancer who are at-risk for Lynch syndrome

Tue Jun 01 00:00:00 UTC 2010

Impact of microsatellite instability (MSI) on survival in high grade endometrial carcinoma.

Gynecologic oncology

Arabi H,Guan H,Kumar S,Cote M,Bandyopadhyay S,Bryant C,Shah J,Abdul-Karim FW,Munkarah AR,Ali-Fehmi R

08-1374 was used in immunohistochemistry - paraffin section to correlate microstellite instability and other clinicopathologic markers with survival of patients with high grade endometrial carcinoma

Fri May 01 00:00:00 UTC 2009

Prognostic value of microsatellite instability determined by immunohistochemical staining of hMSH2 and hMSH6 in urothelial carcinoma of the bladder.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

Mylona E,Zarogiannos A,Nomikos A,Giannopoulou I,Nikolaou I,Zervas A,Nakopoulou L

08-1374 was used in immunohistochemistry - paraffin section to detect expression of MMR gene products hMSH2 and hMSH6 in urothelial carcinoma of the bladder

Tue Jan 01 00:00:00 UTC 2008

生物信息学

蛋白别名: DNA mismatch repair protein Msh6; G/T mismatch-binding protein; GTBP; hMSH6; mutS (E. coli) homolog 6; MutS alpha 160kDa subunit; MutS protein homolog 6; MutS-alpha 160 kDa subunit; MutS-alpha 160kDa subunit; p160; Sperm associated protein; sperm-associated protein

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基因别名: GTBP; GTMBP; HNPCC5; HSAP; MSH6; p160

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UniProt ID: (Human) P52701

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Entrez Gene ID: (Human) 2956

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功能