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产品信息
PA5-106250
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human RPS6KA4(Accession O75676), corresponding to amino acid residues D170-D220.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2853937
产品详细信息
Antibody detects endogenous levels of total MSK2.
靶标信息
RPS6KA4 (MSK2) is a serine/threonine protein kinase that is essential for the regulation of various cellular processes. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. RPS6KA4 contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 90 kDa ribosomal protein S6 kinase 4; coiled-coil domain containing 88B; EC 2.7.11.1; kinase MSK2; KS6A4; mitogen- and stress-activated protein kinase 2; mitogen- and stress-activated protein kinase-2; Nuclear mitogen- and stress-activated protein kinase 2; Ribosomal protein kinase B; ribosomal protein S6 kinase alpha 4; Ribosomal protein S6 kinase alpha-4; ribosomal protein S6 kinase, 90kD, polypeptide 4; ribosomal protein S6 kinase, 90kDa, polypeptide 4; RLSK; RSK-like protein kinase; RSKB; S6K-alpha-4
基因别名: 1110069D02Rik; 90kDa; AI848992; Ccdc88b; mMSK2; MSK2; RPS6KA4; RSK-B; S6K-alpha-4
UniProt ID: (Human) O75676, (Mouse) Q9Z2B9
Entrez Gene ID: (Human) 8986, (Mouse) 56613, (Rat) 361715
magnesium ion binding
protein serine/threonine kinase activity
ribosomal protein S6 kinase activity
protein binding
ATP binding
histone kinase activity (H3-S10 specific)
mitogen-activated protein kinase p38 binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein modifying enzyme
non-receptor serine/threonine protein kinase
negative regulation of cytokine production
regulation of transcription, DNA-templated
protein phosphorylation
inflammatory response
histone phosphorylation
positive regulation of CREB transcription factor activity
positive regulation of histone phosphorylation
positive regulation of histone acetylation
intracellular signal transduction
histone H3-S10 phosphorylation
histone H3-S28 phosphorylation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of NF-kappaB transcription factor activity
interleukin-1-mediated signaling pathway
phosphorylation
