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产品信息
A300-911A
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 665 and the C-terminus (residue 715) of human Metastasis Associated 1.
偶联物
形式
Liquid
浓度
0.20 mg/mL
纯化类型
Antigen affinity chromatography
保存液
TBS, pH 7.0 to 8.0, with 0.1% BSA
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Based on 100% sequence identity, this antibody is predicted to react with Rat
靶标信息
This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: metastasis associated gene 1 protein; Metastasis-associated protein MTA1
基因别名: MTA1
UniProt ID: (Human) Q13330
Entrez Gene ID: (Human) 9112, (Mouse) 116870
core promoter sequence-specific DNA binding
core promoter binding
RNA polymerase II repressing transcription factor binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
transcription corepressor activity
histone deacetylase activity
protein binding
zinc ion binding
DNA binding
enzyme binding
sequence-specific DNA binding
metal ion binding
homeodomain transcription factor
double-strand break repair
transcription, DNA-templated
regulation of transcription, DNA-templated
signal transduction
response to ionizing radiation
histone deacetylation
protein sumoylation
response to lipopolysaccharide
circadian regulation of gene expression
regulation of gene expression, epigenetic
entrainment of circadian clock by photoperiod
proteasome-mediated ubiquitin-dependent protein catabolic process
locomotor rhythm
regulation of inflammatory response
positive regulation of protein autoubiquitination
negative regulation of nucleic acid-templated transcription
secretory granule organization
rhythmic process
regulation of nucleic acid-templated transcription
