Abnova

MTA1 Monoclonal Antibody (4D5)

MTA1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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MTA1 Antibody (H00009112-M01) in IHC (P)

Immunoperoxidase of monoclonal antibody to MTA1 on formalin-fixed paraffin-embedded human esophagus. Antibody concentration is 1.2 µg/mL.

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产品信息

H00009112-M01

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-5 µg/mL

免疫组化（石蜡） (IHC (P))

1.2 µg/mL

酶联免疫吸附实验 (ELISA)

3 ng/mL

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Mouse / IgG3, kappa

分类

Monoclonal

类型

Antibody

克隆号

4D5

抗原

MTA1 (NP_004680, 601 a.a. approximately 700 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

See Label

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Sequence of this protein is as follows: MPSRGLANHG QTRHMGPSRN LLLNGKSYPT KVRLIRGGSL PPVKRRRMNW IDAPDDVFYM ATEETRKIRK LLSSSETKRA ARRPYKPIAL RQSQALPPRP

靶标信息

This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling.

仅用于科研。不用于诊断过程。未经明确授权不得转售。