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产品信息
PA5-19978
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to amino acids 652 to 668 of human PID (6)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11154342
产品详细信息
In Western blot applications, this antibody detects a band at ~75kDa. A suggested positive control is Hela cell lysate.
PA5-19978 can be used with blocking peptide PEP-0102.
靶标信息
This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp686F2281; metastais-associated gene family, member 2; metastasis -associated gene 1-like 1; metastasis associated 1 family, member 2; metastasis associated 1-like 1; metastasis associated gene family, member 2; Metastasis-associated 1-like 1; metastasis-associated gene family, member 2; metastasis-associated protein 2; Metastasis-associated protein MTA2; MTA1-L1 protein; p53 target protein in deacetylase complex
基因别名: AW550797; Mata1l1; mmta2; MTA1L1; MTA2; PID
UniProt ID: (Human) O94776, (Mouse) Q9R190
Entrez Gene ID: (Human) 9219, (Rat) 361724, (Mouse) 23942
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
transcription factor activity, transcription factor binding
RNA polymerase II transcription factor binding
RNA polymerase II repressing transcription factor binding
transcription factor activity, sequence-specific DNA binding
histone deacetylase activity
protein binding
zinc ion binding
nucleosomal DNA binding
histone deacetylase binding
transcription regulatory region DNA binding
DNA binding
chromatin binding
sequence-specific DNA binding
metal ion binding
negative regulation of transcription from RNA polymerase II promoter
DNA methylation
regulation of fibroblast migration
histone deacetylation
ATP-dependent chromatin remodeling
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
chromatin assembly or disassembly
regulation of signal transduction by p53 class mediator
DNA packaging
chromatin remodeling
regulation of transcription, DNA-templated
