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MTF2 Antibody (PA5-35931) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of MTF2 was performed in HeLa cells fixed in 4% paraformaldehyde at RT for 15 min. Green: MTF2 Polyclonal Antibody (Product # PA5-35931) diluted at 1:250. Red: phalloidin, a cytoskeleton marker. Scale bar = 10 µm.
产品信息
PA5-35931
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 401 and 593 of MTF2
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_2553241
产品详细信息
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Predicted reactivity: Mouse (95%), Rat (95%), Chicken (92%), Bovine (100%).
靶标信息
Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hPCl2; Metal regulatory transcription factor 2; metal response element DNA-binding protein M96; metal response element-binding transcription factor 2; Metal-response element DNA-binding protein M96; Metal-response element-binding transcription factor 2; mPCl2; polycomb-like 2; Polycomb-like protein 2; putative DNA binding protein; RP5-976O13.1; tudor domain containing 19A; Zinc-regulated factor 1; ZiRF1
基因别名: 9230112N11Rik; AA537621; C76717; dJ976O13.2; M96; MTF2; PCL2; TDRD19A
UniProt ID: (Human) Q9Y483, (Mouse) Q02395
Entrez Gene ID: (Human) 22823, (Mouse) 17765
negative regulation of transcription from RNA polymerase II promoter
segment specification
covalent chromatin modification
stem cell population maintenance
negative regulation of gene expression, epigenetic
positive regulation of transcription from RNA polymerase II promoter
stem cell differentiation
negative regulation of histone H3-K27 methylation
positive regulation of histone H3-K27 methylation
chromatin modification
