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MTMR2 Antibody (PA5-97174) in WB
Western blot analysis of MTMR2 in extracts of various cell lines. Samples were incubated with MTMR2 Polyclonal antibody (Product # PA5-97174) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
产品信息
PA5-97174
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 404-643 of human MTMR2 (NP_0572403)
偶联物
形式
Liquid
浓度
2.09 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2808976
产品详细信息
Immunogen sequence: DKVESGKTSV VVHCSDGWDR TAQLTSLAML MLDGYYRTIR GFEVLVEKEW LSFGHRFQLR VGHGDKNHAD ADRSPVFLQF IDCVWQMTRQ FPTAFEFNEY FLITILDHLY SCLFGTFLCN SEQQRGKENL PKRTVSLWSY INSQLEDFTN PLYGSYSNHV LYPVASMRHL ELWVGYYIRW NPRMKPQEPI HNRYKELLAK RAELQKKVEE LQREISNRST SSSERASSPA QCVTPVQTVV; Positive Samples: HeLa, Jurkat, U-87MG, Mouse brain, Mouse kidney, Mouse liver, Rat liver; Cellular Location: Cytoplasm, Early endosome membrane, Peripheral membrane protein
靶标信息
This gene is a member of the myotubularin family. The encoded protein possesses phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive demyelinating neuropathy. Multiple alternatively spliced transcript variants have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Myotubularin-related protein 2; phosphatidylinositol-3,5-bisphosphate 3-phosphatase; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2; phosphatidylinositol-3-phosphatase; Phosphatidylinositol-3-phosphate phosphatase; phosphoinositide-3-phosphatase
基因别名: 6030445P13Rik; CMT4B; CMT4B1; KIAA1073; MTMR2
UniProt ID: (Human) Q13614, (Mouse) Q9Z2D1
Entrez Gene ID: (Human) 8898, (Mouse) 77116, (Rat) 315422
phosphatidylinositol-3-phosphatase activity
protein tyrosine phosphatase activity
protein binding
protein tyrosine/serine/threonine phosphatase activity
protein homodimerization activity
phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
hydrolase activity
phosphatase activity
phosphatidylinositol phosphate phosphatase activity
phosphatase
negative regulation of receptor internalization
protein dephosphorylation
phosphatidylinositol biosynthetic process
negative regulation of myelination
myelin assembly
peptidyl-tyrosine dephosphorylation
negative regulation of endocytosis
inositol phosphate dephosphorylation
phosphatidylinositol dephosphorylation
neuron development
protein tetramerization
negative regulation of excitatory postsynaptic potential
dendritic spine maintenance
positive regulation of early endosome to late endosome transport
negative regulation of receptor catabolic process
lipid metabolic process
dephosphorylation
phosphatidylinositol metabolic process
