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MTMR4 Antibody (PA5-13711) in IHC (P)
Immunohistochemistry analysis of MTMR4 in formalin-fixed and paraffin-embedded human hepatocarcinoma tissue. Samples were incubated with MTMR4 polyclonal antibody (Product # PA5-13711) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
产品信息
PA5-13711
产品规格
种属反应
Human,
Mouse
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 1155-1187 amino acids from the C-terminal region of human MTMR4
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Size-exclusion - Dialysis, Ammonium sulfate precipitation
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2147962
靶标信息
MTMR, a member of the myotubularin family, encodes an intracellular protein of 1, 195 amino acids, and shares approximately 47% sequence identity with MTMR3, spiking to over 70% identity in the catalytic domain and the double zinc finger (FYVE) motif. PCR analysis detects expression of MTMR4 in all human tissues examined except lung, small intestine, stomach, salivary gland, adrenal gland, and uterus. Subcellular localization of MTMR4 in transfected HeLa cells showed a perinuclear distribution, similar to that seen with MTMR3. MTMR4 dephosphorylates para-nitrophenylphosphate and phosphatidylinositol 3-phosphate.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: DKFZp781E194; FYVE domain-containing dual specificity protein phosphatase 2; FYVE zinc finger phosphatase; FYVE-DSP2; MGC163449; MGC163451; MTMR7; Myotubularin-related protein 4; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4; Phosphatidylinositol-3-phosphate phosphatase; Zinc finger FYVE domain-containing protein 11; zinc finger, FYVE domain containing 11
基因别名: AA596759; ESTM44; FYVE-DSP2; KIAA0647; mKIAA0647; MTMR4; ZFYVE11
UniProt ID: (Human) Q9NYA4, (Mouse) Q91XS1
Entrez Gene ID: (Human) 9110, (Mouse) 170749
phosphatidylinositol-3-phosphatase activity
protein serine/threonine phosphatase activity
protein tyrosine phosphatase activity
protein binding
metal ion binding
phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
phosphoprotein phosphatase activity
hydrolase activity
phosphatase activity
phosphatase
protein dephosphorylation
phosphatidylinositol biosynthetic process
transforming growth factor beta receptor signaling pathway
response to denervation involved in regulation of muscle adaptation
negative regulation of transforming growth factor beta receptor signaling pathway
peptidyl-tyrosine dephosphorylation
dephosphorylation
