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产品信息
H00004585-M07J
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
5B12
抗原
MUC4 (NP_004523, 79 a.a. approximately 188 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: GVSLFPYGAD AGDLEFVRRT VDFTSPLFKP ATGFPLGSSL RDSLYFTDNG QIIFPESDYQ IFSYPNPLPT GFTGRDPVAL VAPFWDDADF STGRGTTFYQ EYETFYGEHS
靶标信息
Nearly all mucosal surfaces are protected by mucin transmembrane glycoproteins, from bronchioles to corneas to reproductive tracts. Mucin 4 (MUC4) is membrane-bound and is important in protecting and lubricating. MUC4 expression is erroneous in many carcinomas and sarcomas, including fibromyoxoid sarcoma and pancreatic adenocarcinoma. Immunohistochemical staining for MUC4 has been discussed as a potential biomarker for detection of these cancers. MUC4 seems to be most predominantly affected in Asian diseases - Taiwanese infertility and endometriosis, as well as gallstone formation in Chinese men, are connected to MUC4, where similar diseases in other populations do not share these MUC4 mutations. Because MUC4 is so important in mucosal surface protection, it is not surprising that it has been implicated as failing in many metastatic cancer invasions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ascites sialoglycoprotein; ASGP; ASGP1; MUC-4; mucin 4, tracheobronchial; Mucin-4; Mucin4; Pancreatic adenocarcinoma mucin; Testis mucin; Tracheobronchial mucin
基因别名: ASGP; HSA276359; MUC-4; MUC4
UniProt ID: (Human) Q99102
Entrez Gene ID: (Human) 4585
