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产品信息
MA5-32725
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JM19-36
抗原
Recombinant protein within Human MUC4 (aa 4,751-4,950).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2810002
产品详细信息
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
Nearly all mucosal surfaces are protected by mucin transmembrane glycoproteins, from bronchioles to corneas to reproductive tracts. Mucin 4 (MUC4) is membrane-bound and is important in protecting and lubricating. MUC4 expression is erroneous in many carcinomas and sarcomas, including fibromyoxoid sarcoma and pancreatic adenocarcinoma. Immunohistochemical staining for MUC4 has been discussed as a potential biomarker for detection of these cancers. MUC4 seems to be most predominantly affected in Asian diseases - Taiwanese infertility and endometriosis, as well as gallstone formation in Chinese men, are connected to MUC4, where similar diseases in other populations do not share these MUC4 mutations. Because MUC4 is so important in mucosal surface protection, it is not surprising that it has been implicated as failing in many metastatic cancer invasions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ascites sialoglycoprotein; ASGP; ASGP1; MUC-4; mucin 4, tracheobronchial; Mucin-4; Mucin4; Pancreatic adenocarcinoma mucin; pre-sialomucin complex; sialomucin ascites sialoglycoprotein-1; sialomucin complex; Testis mucin; Tracheobronchial mucin
基因别名: ASGP; ASGP-1; HSA276359; MUC-4; MUC4; Psmc
UniProt ID: (Human) Q99102
Entrez Gene ID: (Human) 4585, (Rat) 303887
negative regulation of cell-matrix adhesion
hematopoietic progenitor cell differentiation
negative regulation of T cell mediated cytotoxicity directed against tumor cell target
cell-matrix adhesion
lactation
response to hormone
regulation of receptor activity
negative regulation of cell-cell adhesion
maintenance of gastrointestinal epithelium
mammary gland development
post-embryonic camera-type eye development
response to estradiol
response to progesterone
cellular response to insulin stimulus
response to vitamin A
response to cytokine
response to drug
negative regulation of apoptotic process
estrous cycle
response to antibiotic
digestive tract development
cellular response to transforming growth factor beta stimulus
O-glycan processing
