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产品信息
PA5-29550
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 1 and 352 of Human MUL1
偶联物
形式
Liquid
浓度
1.88 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2547026
产品详细信息
Recommended positive controls: A431, A431 membrane extract.
Predicted reactivity: Mouse (90%), Rat (91%), Rhesus Monkey (100%), Bovine (82%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
E3 ubiquitin-protein ligase that plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: E3 SUMO-protein ligase MUL1; E3 ubiquitin ligase; E3 ubiquitin-protein ligase MUL1; Growth inhibition and death E3 ligase; mitochondria-anchored protein ligase; mitochondrial E3 ubiquitin ligase 1; mitochondrial ubiquitin ligase activator of NF-kB; Mitochondrial ubiquitin ligase activator of NFKB 1; Mitochondrial-anchored protein ligase; Protein Hades; Putative NF-kappa-B-activating protein 266; RING finger protein 218; RING-type E3 ubiquitin transferase NFKB 1; RP11-401M16.2
基因别名: C1orf166; GIDE; MAPL; MUL1; MULAN; RNF218
UniProt ID: (Human) Q969V5
Entrez Gene ID: (Human) 79594
mitochondrial fission
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
activation of JUN kinase activity
negative regulation of mitochondrial fusion
regulation of mitochondrion organization
protein ubiquitination
protein sumoylation
negative regulation of cell growth
protein destabilization
positive regulation of protein sumoylation
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of innate immune response
negative regulation of defense response to virus by host
protein stabilization
mitochondrion localization
regulation of mitochondrial membrane potential
negative regulation of protein kinase B signaling
negative regulation of type I interferon-mediated signaling pathway
cellular response to exogenous dsRNA
negative regulation of chemokine (C-C motif) ligand 5 production
positive regulation of mitochondrial fission
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
positive regulation of dendrite extension
