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Recommended positive controls: HeLa, Molt-4, Neuro2A, GL261, C8D30, BCL-1, Raw264.7.
Predicted reactivity: Mouse (90%), Rat (90%), Dog (91%), Cat (93%), Bovine (88%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.
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仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Lung resistance-related protein; Major vault protein; MVP; MVP1; Testicular Secretory Protein Li 30; VAULT1; vRNP
基因别名: 2310009M24Rik; LRP; MVP; VAULT1
UniProt ID: (Human) Q14764, (Mouse) Q9EQK5
Entrez Gene ID: (Human) 9961, (Mouse) 78388