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产品信息
PA5-57225
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein corresponding to Human MXI1. Recombinant protein control fragment (Product #RP-95284).
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2644322
产品详细信息
Immunogen sequence: HTTLGLLNKA KAHIKKLEEA ERKSQHQLEN LEREQRFLKW RLEQLQGPQE MERIRM
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.
靶标信息
It is now well established that Myc regulation of cell proliferation and differentiation involves a family of related transcription factors. One such factor, Max, is an obligate heterodimeric partner for Myc and can also form heterodimers with at least four related proteins designated Mad 1, Mxi1, Mad 3 and Mad 4. Like Mad 1 and Mxi1, association of Mad 3 and Mad 4 with Max results in transcriptional repression. Both Myc and the Mad proteins have short half-lives and their synthesis is tightly regulated, while Max expression is constitutive and relatively stable. Two related mammalian cDNAs have been identified and shown to encode Mad-binding proteins. Both possess sequence homology with the yeast transcription repressor Sin3 including four conserved paired amphipathic helix (PAH) domains. mSin3A and mSin3B specifically interact with the Mad proteins via their second paired amphipathic helix domain (PAH2). It has been suggested that Mad-Max heterodimers repress transcription by tethering mSin3 to DNA as corepressors.
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生物信息学
蛋白别名: bHLHc11; Class C basic helix-loop-helix protein 11; MAX dimerization protein 2; Max interactor 1; Max-interacting protein 1; Max-related transcription factor; MGC43220; RP11-549L6.1
基因别名: BHLHC11; MAD2; MXD2; MXI; MXI1
UniProt ID: (Human) P50539
Entrez Gene ID: (Human) 4601
