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产品信息
PA5-144100
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human Myeloid-associated differentiation marker protein (1-40AA)
偶联物
形式
Liquid
浓度
2.02 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% Proclin 300
保存条件
-20°C or -80°C if preferred
运输条件
Wet ice
RRID
AB_3091492
靶标信息
MYADM, belonging to the MAL family, is a 322-amino acid protein having 7 hydrophobic transmembrane domains, several potential consensus sites for phosphorylation and sequence homology with the T-cell differentiation protein MAL and plasmolipin. It shares 75.8% sequence identity with mouse in the transmembrane regions and is associated with differentiation of hematopoietic cells or acute promyelocytic leukemia cells. Its expression is up-regulated in NB4 cells induced by all-trans retinoic acid whereas down regulation inhibits colony formation of bone marrow cells. MYADM could serve as a new marker for hematopoietic differentiation and is a target for diagnostic, prognostic and/or therapeutic interventions. It is known to express widely in brain and pancreatic islet cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: myeloid upregulated protein; Myeloid-associated differentiation marker; Protein SB135
基因别名: MYADM; SB135; UNQ553/PRO1110
UniProt ID: (Human) Q96S97
Entrez Gene ID: (Human) 91663
negative regulation of protein phosphorylation
negative regulation of gene expression
regulation of cell-substrate adhesion
positive regulation of cell migration
negative regulation of actin filament polymerization
membrane raft organization
negative regulation of heterotypic cell-cell adhesion
cell-cell junction maintenance
establishment of endothelial barrier
protein targeting to plasma membrane
negative regulation of protein kinase C signaling
positive regulation of substrate adhesion-dependent cell spreading
