Invitrogen

MYBPC3 Polyclonal Antibody

MYBPC3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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MYBPC3 Antibody (PA5-71701) in IHC (P)

Immunohistochemistry analysis of MYBPC3 in paraformaldehyde-fixed, paraffin-embedded human skeletal muscle tissue sections. Samples were incubated with MYBPC3 polyclonal antibody (Product # PA5-71701) using a dilution of 1:25 for 1 hours at 37°C followed by an undiluted biotinylated goat polyvalent antibody. Tissue was fixed with formaldehyde and blocked with 3% BSA for 0.5 hour at room temperature; antigen... View More

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产品信息

PA5-71701

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:2,000

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免疫组化（石蜡） (IHC (P))

1:25

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide between 189-218 amino acids from the N-terminal region of human MYBPC3

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein A, Antigen affinity chromatography

保存液

PBS, pH 7.4

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2717555

靶标信息

Myosin binding protein C, cardiac-type (MYBPC3) is a thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments. It modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. Mutations affecting the gene can result in cardiomyopathy - familial hypertrophic 4, cardiomyopathy - dilated 1MM, or left ventricular non-compaction 10.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Ca2+/calmodulin-dependent protein kinase II and protein kinase G oxidation contributes to impaired sarcomeric proteins in hypertrophy model.

ESC heart failure

Gömöri K,Herwig M,Budde H,Hassoun R,Mostafi N,Zhazykbayeva S,Sieme M,Modi S,Szabados T,Pipis J,Farkas-Morvay N,Leprán I,Ágoston G,Baczkó I,Kovács Á,Mügge A,Ferdinandy P,Görbe A,Bencsik P,Hamdani N

PA5-71701 was used in Immunohistochemistry (Paraffin), Western Blot to show VO-induced cardiomyocyte dysfunction via deranged phosphorylation of myofilament proteins and signalling pathways due to increased oxidative state of CaMKII and PKG and this might contribute to the development of hypertrophy.

Mon Aug 01 00:00:00 UTC 2022

De Novo Missense Mutations in TNNC1 and TNNI3 Causing Severe Infantile Cardiomyopathy Affect Myofilament Structure and Function and Are Modulated by Troponin Targeting Agents.

International journal of molecular sciences

Hassoun R,Budde H,Mannherz HG,Lódi M,Fujita-Becker S,Laser KT,Gärtner A,Klingel K,Möhner D,Stehle R,Sultana I,Schaaf T,Majchrzak M,Krause V,Herrmann C,Nowaczyk MM,Mügge A,Pfitzer G,Schröder RR,Hamdani N,Milting H,Jaquet K,Cimiotti D

PA5-71701 was used in Western Blotting to investigate the interaction of troponin variants, TNNC1 and TNNCI3, with actin and their inter-subunit interactions, as well as the structural integrity of reconstituted thin filaments.

Mon Sep 06 00:00:00 UTC 2021

De Novo Missense Mutations in TNNC1 and TNNI3 Causing Severe Infantile Cardiomyopathy Affect Myofilament Structure and Function and Are Modulated by Troponin Targeting Agents.

International journal of molecular sciences

Mon Sep 06 00:00:00 UTC 2021

生物信息学

蛋白别名: C-protein, cardiac muscle isoform; cardiac C-protein; Cardiac MyBP-C; DKFZp779E1762; Myosin-binding protein C, cardiac-type; truncated cardiac myosin-binding protein C

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基因别名: CMD1MM; CMH4; FHC; LVNC10; MYBP-C; MYBPC3

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UniProt ID: (Human) Q14896, (Rat) P56741

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Entrez Gene ID: (Human) 4607, (Rat) 295929, (Mouse) 17868

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功能