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MYLK Antibody (H00004638-D01P) in WB
Western Blot analysis of MYLK expression in transfected 293T cell line (H00004638-T01) by MYLK MaxPab polyclonal antibody.
Lane 1: MYLK transfected lysate(110.20 KDa).
Lane 2: Non-transfected lysate.
Lane 1: MYLK transfected lysate(110.20 KDa).
Lane 2: Non-transfected lysate.
产品信息
H00004638-D01P
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
MYLK (ENSP00000355024, 1 a.a. approximately 992 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MDFRANLQRQ VKPKTVSEEE RKVHSPQQVD FRSVLAKKGT SKTPVPEKVP PPKPATPDFR SVLGGKKKLP AENGSSSAET LNAKAVESSK PLSNAQPSGP LKPVGNAKPA ETLKPMGNAK PAETLKPMGN AKPDENLKSA SKEELKKDVK NDVNCKRGHA GTTDNEKRSE SQGTAPAFKQ KLQDVHVAEG KKLLLQCQVS SDPPATIIWT LNGKTLKTTK FIILSQEGSL CSVSIEKALP EDRGLYKCVA KNDAGQAECS CQVTVDDAPA SENTKAPEMK SRRPKSSLPP VLGTESDATV KKKPAPKTPP KAAMPPQIIQ FPEDQKVRAG ESVELFGKVT GTQPITCTWM KFRKQIQESE HMKVENSENG SKLTILAARQ EHCGCYTLLV ENKLGSRQAQ VNLTVVDKPD PPAGTPCASD IRSSSLTLSW YGSSYDGGSA VQSYSIEIWD SANKTWKELA TCRSTSFNVQ DLLPDHEYKF RVRAINVYGT SEPSQESELT TVGEKPEEPK DEVEVSDDDE KEPEVDYRTV TINTEQKVSD FYDIEERLGS GKFGQVFRLV EKKTRKVWAG KFFKAYSAKE KENIRQEISI MNCLHHPKLV QCVDAFEEKA NIVMVLEIVS GGELFERIID EDFELTEREC IKYMRQISEG VEYIHKQGIV HLDLKPENIM CVNKTGTRIK LIDFGLARRL ENAGSLKVLF GTPEFVAPEV INYEPIGYAT DMWSIGVICY ILVSGLSPFM GDNDNETLAN VTSATWDFDD EAFDEISDDA KDFISNLLKK DMKNRLDCTQ CLQHPWLMKD TKNMEAKKLS KDRMKKYMAR RKWQKTGNAV RAIGRLSSMA MISGLSGRKS STGSPTSPLN AEKLESEEDV SQAFLEAVAE EKPHVKPYFS KTIRDLEVVE GSAARFDCKI EGYPDPEVVW FKDDQSIRES RHFQIDYDED GNCSLIISDV CGDDDAKYTC KAVNSLGEAT CTAELIVETM EEGEGEGEEE EE
靶标信息
MYLK (MLCK) is a serine/threonine kinase that phosphorylates myosin regulatory light chains to assist in the production of contractile activity (myosin-actin interaction). MLCK is responsible for smooth muscle contraction via phosphorylation of a specific serine in the N-terminus of myosin light chains (MLC), an event that facilitates myosin interaction with actin filaments. It is a central determinant in the development of vascular permeability and tissue edema formation. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. MLCK acts as a critical participant in signaling sequences that result in fibroblast apoptosis. Smooth muscle and non-muscle isozymes are expressed in a wide variety of adult and fetal tissues and in cultured endothelium with qualitative expression appearing to be neither tissue- nor development-specific. Non-muscle isoform 2 is the dominant splice variant expressed in various tissues. The Telokin isoform, which binds calmodulin, has been found in a wide variety of adult and fetal tissues. MLCK is probably down-regulated by phosphorylation. The protein contains 1 fibronectin type III domain and 9 immunoglobulin-like C2-type domains.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Kinase-related protein; KRP; MLCK; Myosin light chain kinase, smooth muscle; myosin, light polypeptide kinase; smooth muscle myosin light chain kinase; Telokin
基因别名: AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210; MSTP083; MYLK; MYLK1; smMLCK
UniProt ID: (Human) Q15746
Entrez Gene ID: (Human) 4638
positive regulation of defense response to virus by host
protein phosphorylation
muscle contraction
smooth muscle contraction
tonic smooth muscle contraction
positive regulation of cell migration
bleb assembly
positive regulation of calcium ion transport
aorta smooth muscle tissue morphogenesis
cellular hypotonic response
positive regulation of wound healing
mitophagy in response to mitochondrial depolarization
xenophagy
