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产品信息
PA5-101688
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human MYO9B(Accession Q13459), corresponding to amino acid residues S303-F353.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2851122
产品详细信息
Antibody detects endogenous levels of total MYO9B.
靶标信息
This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: celiac disease 4; myosin; myosin-IXb; myr 5; Unconventional myosin from rat 3; unconventional myosin IXb; Unconventional myosin-9b; Unconventional myosin-IXb
基因别名: CELIAC4; MYO9B; MYR5
UniProt ID: (Human) Q13459
Entrez Gene ID: (Human) 4650, (Mouse) 17925, (Rat) 25486
microfilament motor activity
actin binding
GTPase activator activity
protein binding
calmodulin binding
ATP binding
zinc ion binding
ATPase activity
Rho GTPase binding
actin-dependent ATPase activity
protein homodimerization activity
ATP-dependent protein binding
ADP binding
Roundabout binding
actin filament binding
nucleotide binding
motor activity
metal ion binding
Rho protein signal transduction
actin filament-based movement
ARF protein signal transduction
regulation of Rho protein signal transduction
Roundabout signaling pathway
positive regulation of GTPase activity
regulation of small GTPase mediated signal transduction
monocyte chemotaxis
signal transduction
metabolic process
establishment of cell polarity
actin-myosin filament sliding
intracellular signal transduction
macrophage chemotaxis
lamellipodium morphogenesis
