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MYOC Antibody (H00004653-D01P) in WB
Western Blot analysis of MYOC expression in transfected 293T cell line (H00004653-T02) by MYOC MaxPab polyclonal antibody.
Lane 1: MYOC transfected lysate(57.00 KDa).
Lane 2: Non-transfected lysate.
Lane 1: MYOC transfected lysate(57.00 KDa).
Lane 2: Non-transfected lysate.
产品信息
H00004653-D01P
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
MYOC (NP_000252.1, 1 a.a. approximately 504 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MRFFCARCCS FGPEMPAVQL LLLACLVWDV GARTAQLRKA NDQSGRCQYT FSVASPNESS CPEQSQAMSV IHNLQRDSST QRLDLEATKA RLSSLESLLH QLTLDQAARP QETQEGLQRE LGTLRRERDQ LETQTRELET AYSNLLRDKS VLEEEKKRLR QENENLARRL ESSSQEVARL RRGQCPQTRD TARAVPPGSR EVSTWNLDTL AFQELKSELT EVPASRILKE SPSGYLRSGE GDTGCGELVW VGEPLTLRTA ETITGKYGVW MRDPKPTYPY TQETTWRIDT VGTDVRQVFE YDLISQFMQG YPSKVHILPR PLESTGAVVY SGSLYFQGAE SRTVIRYELN TETVKAEKEI PGAGYHGQFP YSWGGYTDID LAVDEAGLWV IYSTDEAKGA IVLSKLNPEN LELEQTWETN IRKQSVANAF IICGTLYTVS SYTSADATVN FAYDTGTGIS KTLTIPFKNR YKYSSMIDYN PLEKKLFAWD NLNMVTYDIK LSKM
靶标信息
Myocilin is an extracellular protein expressed in the eye, including the retina, trabecular meshwork and ciliary body. Myocilin can form homomultimers in vivo and can also associate with components of the ECM via interactions with the Hep II domain of FibroPVRL1. In addition, myocilin interacts with myosin regulatory light chain, a component of the myosin motor protein complex. This interaction implies a role for myocilin in the actomyosin system, linking myocilin to the functional status of the trabecular meshwork (TM), which is responsible for controlling the intraocular pressure (IOP). Alterations in functions of the TM may lead to IOP elevation and development of glaucoma, a major cause of blindness. Myocilin is encoded by MYOC (also designated TIGR), a gene that maps to the GLC1A locus on chromosome 1q24. 3 and is susceptible to mutations. Mutations in the MYOC gene are specifically linked with primary open angle glaucoma (POAG), a blinding disease characterized by progressive loss of retinal ganglion cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: juvenile-onset open-angle glaucoma 1; mutated trabecular meshwork-induced glucocorticoid response protein; Myocilin; Myocilin 55 kDa subunit; myocilin trabecular meshwork inducible glucocorticoid response; myocilin trabecular meshwork inducible glucocorticoid response protein; myocilin, trabecular meshwork inducible glucocorticoid response; trabecular meshwork inducible glucocorticoid response protein; Trabecular meshwork-induced glucocorticoid response protein
基因别名: GLC1A; GPOA; JOAG; JOAG1; MYOC; TIGR
UniProt ID: (Human) Q99972, (Rat) Q9R1J4
Entrez Gene ID: (Human) 4653, (Rat) 81523
osteoblast differentiation
negative regulation of cell-matrix adhesion
positive regulation of phosphatidylinositol 3-kinase signaling
skeletal muscle hypertrophy
myelination in peripheral nervous system
positive regulation of cell migration
neuron projection development
negative regulation of Rho protein signal transduction
non-canonical Wnt signaling pathway via JNK cascade
ERBB2-ERBB3 signaling pathway
regulation of MAPK cascade
clustering of voltage-gated sodium channels
positive regulation of stress fiber assembly
negative regulation of stress fiber assembly
positive regulation of focal adhesion assembly
positive regulation of protein kinase B signaling
positive regulation of mitochondrial depolarization
bone development
positive regulation of substrate adhesion-dependent cell spreading
nerve development
cellular response to nerve growth factor stimulus
