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产品信息
PA5-107186
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the N-terminal region of Mouse Myocd
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.4, with 2% sucrose
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2817902
产品详细信息
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 85%
靶标信息
Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Basic SAP coiled-coil transcription activator 2; Myocardin; SRF co-factor protein (cardiac and smooth muscle); SRF cofactor protein
基因别名: Bsac2; BSAC2A; Mycd; Myocd; Srfcp
UniProt ID: (Mouse) Q8VIM5
Entrez Gene ID: (Mouse) 214384
core promoter sequence-specific DNA binding
transcription factor activity, RNA polymerase II transcription factor binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription coactivator activity
protein binding
transcription factor binding
histone acetyltransferase binding
histone deacetylase binding
R-SMAD binding
DNA-binding transcription factor
negative regulation of transcription from RNA polymerase II promoter
regulation of cell growth by extracellular stimulus
vasculogenesis
cardiac ventricle development
positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
heart development
positive regulation of cell proliferation
negative regulation of cell proliferation
negative regulation of cardiac muscle cell apoptotic process
negative regulation of myotube differentiation
positive regulation of transforming growth factor beta receptor signaling pathway
regulation of histone acetylation
hepatic stellate cell activation
muscle cell differentiation
positive regulation of DNA binding
cellular component maintenance
regulation of myoblast differentiation
negative regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of smooth muscle contraction
lung alveolus development
digestive tract development
positive regulation of sequence-specific DNA binding transcription factor activity
smooth muscle cell differentiation
regulation of smooth muscle cell differentiation
positive regulation of smooth muscle cell differentiation
cardiac muscle cell differentiation
ventricular cardiac muscle cell differentiation
uterus development
urinary bladder development
cell growth involved in cardiac muscle cell development
ductus arteriosus closure
negative regulation of beta-amyloid clearance
positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
positive regulation of cardiac vascular smooth muscle cell differentiation
positive regulation of cardiac muscle cell differentiation
negative regulation of skeletal muscle cell differentiation
