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MYOCD Antibody (PA5-95700) in IHC (P)
Immunohistochemistry analysis of MYOCD in paraffin-embedded rat brain. Samples were incubated with MYOCD Polyclonal antibody (Product # PA5-95700) using a dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
产品信息
PA5-95700
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 680-780 of human MYOCD (NP_7058321)
偶联物
形式
Liquid
浓度
0.77 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2807502
产品详细信息
Positive Samples: Rat heart; Cellular Location: Nucleus
Immunogen sequence: SQVCTAQMAG LHSSDKVGPK FSIPSPTFSK SSSAISEVTQ PPSYEDAVKQ QMTRSQQMDE LLDVLIESGE MPADAREDHS CLQKVPKIPR SSRSPTAVLT K
靶标信息
Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Myocardin; transcription factor myocardin
基因别名: MYCD; MYOCD
UniProt ID: (Human) Q8IZQ8, (Rat) Q8R5I7
Entrez Gene ID: (Human) 93649, (Rat) 246297
core promoter sequence-specific DNA binding
transcription factor activity, RNA polymerase II transcription factor binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription coactivator activity
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
protein binding
transcription factor binding
histone acetyltransferase binding
histone deacetylase binding
R-SMAD binding
molecular_function
transcription coactivator activity
DNA-binding transcription factor
negative regulation of transcription from RNA polymerase II promoter
regulation of cell growth by extracellular stimulus
vasculogenesis
response to hypoxia
cardiac ventricle development
positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
transcription from RNA polymerase II promoter
positive regulation of cell proliferation
negative regulation of cell proliferation
negative regulation of cardiac muscle cell apoptotic process
negative regulation of myotube differentiation
positive regulation of transforming growth factor beta receptor signaling pathway
cardiocyte differentiation
regulation of histone acetylation
hepatic stellate cell activation
vascular smooth muscle cell differentiation
positive regulation of DNA binding
cellular component maintenance
regulation of myoblast differentiation
negative regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of smooth muscle contraction
lung alveolus development
digestive tract development
positive regulation of sequence-specific DNA binding transcription factor activity
smooth muscle cell differentiation
regulation of smooth muscle cell differentiation
positive regulation of smooth muscle cell differentiation
cardiac muscle cell differentiation
ventricular cardiac muscle cell differentiation
uterus development
urinary bladder development
cell growth involved in cardiac muscle cell development
cellular response to growth factor stimulus
cellular response to hypoxia
ductus arteriosus closure
negative regulation of beta-amyloid clearance
regulation of phenotypic switching
positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
positive regulation of cardiac vascular smooth muscle cell differentiation
positive regulation of cardiac muscle cell differentiation
negative regulation of skeletal muscle cell differentiation
regulation of transcription from RNA polymerase II promoter
heart development
muscle cell differentiation
