Invitrogen

Macrophages (Mature) Monoclonal Antibody (25F9), FITC

产品信息

MA5-49063

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:50

免疫组化（石蜡） (IHC (P))

1:50

免疫组化（冰冻） (IHC (F))

1:50

流式细胞分析 (Flow)

1:50

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

25F9

抗原

The monoclonal antibody 25F9 recognizes a protein of 86 kD on the cell surface and within the cytoplasm of mature macrophages

偶联物

FITC FITC FITC

激发/发射光谱

498/517 nm 查看光谱

形式

Liquid

浓度

100 µg/mL

纯化类型

Protein G

保存液

PBS with 1% BSA

内含物

0.02% sodium azide

保存条件

4° C, store in dark

运输条件

Wet ice

AB_3090514

产品详细信息

The antibody is associated with fully differentiated tissue macrophages both in normal and in diseased tissues, independently of the presence or absence of inflammation. The antigen is absent on freshly isolated monocytes and other blood cells. After 6 to 7 days culture human monocytes become positive. Some melanoma and carcinoma cell lines are also positive. Furthermore the monoclonal antibody 25F9 cross reacts with a subpopulation of macrophages of rhesus monkey, pig alveolar macrophages and Kupffer cells.

靶标信息

Macrophages are a type of white blood cell that plays a crucial role in the immune system. They are responsible for detecting, engulfing, and destroying foreign substances, such as bacteria and viruses, as well as dead cells and debris. Mature macrophages are found in various tissues throughout the body and are highly specialized to perform specific functions depending on their location. For example, alveolar macrophages are found in the lungs and are responsible for removing foreign particles that are inhaled, while Kupffer cells are found in the liver and are responsible for removing old or damaged red blood cells. Understanding the function and behavior of macrophages is crucial for developing new treatments for diseases such as cancer, autoimmune disorders, and infections.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: casein kinase 1, alpha 1; casein kinase 1, alpha 1-like; casein kinase I alpha S-like; Casein kinase I isoform alpha; Casein kinase I isoform alpha-like; CASP-1; CASP1 nirs variant 1; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); Caspase-1; CK1; CKI-alpha; CKI-alpha-like; clock regulator kinase; down-regulated in lung cancer; epididymis secretory sperm binding protein Li 77p; ICE; IL-1 beta-converting enzyme; IL-1BC; IL1B-convertase; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; Macrophages; Mature Macrophages; p45

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基因别名: CASP1; CK1; CK1a; CKIa; CSNK1A1; CSNK1A1L; HEL-S-77p; HLCDGP1; ICE; IL1BC; IL1BCE; P45; PRO2975

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UniProt ID: (Human) P29466, (Human) P48729, (Human) Q8N752

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Entrez Gene ID: (Human) 834, (Human) 1452, (Human) 122011

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