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MafA Antibody (A300-611A) in WB
Detection of MafA, MafB and cMaf by western blot. Samples: Nuclear extract (6 µg) from HeLa cells transfected with MafA, MafB or cMaf expression constructs. Antibodies: Affinity purified anti-MafA antibody BL1069 (Product # A300-611A), anti-MafB Antibody (Product #A300-612A) or anti-c-Maf antibody BL662 (Product #A300-613A). Each antibody was used at 0.5 µg/mL. Detection: Chemiluminescence with a 5 second exposure.
产品信息
A300-611A
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 300 and the C-terminus (residue 359) of mouse v-maf musculoaponeurotic fibrosarcoma oncogene homolog A.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
tris citrate/phosphate, pH 7-8
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Human
靶标信息
MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene. MAFA cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its ocogenic activity. Serves as an ocogene or tumor supressor depending on the cell context.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Mafa homolog; Pancreatic beta-cell-specific transcriptional activator; Transcription factor MafA; V-maf musculoaponeurotic fibrosarcoma oncogene homolog A
基因别名: Mafa; RIPE3b1
UniProt ID: (Mouse) Q8CF90
Entrez Gene ID: (Mouse) 378435
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
basic leucine zipper transcription factor
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
nitric oxide mediated signal transduction
response to glucose
insulin secretion
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
