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MeCP2 isoform 2 Polyclonal Antibody

查看其他3个MeCP2 Isoform 2抗体

抗体检测数据 (1)

MeCP2 isoform 2 Antibody in Immunohistochemistry (IHC)

MeCP2 isoform 2 Antibody in Immunohistochemistry (IHC)

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MeCP2 isoform 2 Antibody (MECP2-201AP) in IHC

Anti-MeCP2 isoform 2 antibody dilution 1:100. Primary antibodies incubate over night at 37°C. Secondary antibodies incubate for 2 hours at 37°C. Used WT and -e1/y male brains. Data courtesy of product review submitted by Dr. Dag Yasui.

MeCP2 isoform 2 Antibody in Immunohistochemistry (IHC)

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MeCP2 isoform 2 Antibody in Immunohistochemistry (IHC) — Anti-MeCP2 isoform 2 antibody dilution 1:100. Primary antibodies incubate over night at 37°C. Secondary antibodies incubate for 2 hours at 37°C. Used WT and -e1/y male brains. Data courtesy of product review submitted by Dr. Dag Yasui.

产品信息

MECP2-201AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

-

免疫组化 (IHC)

1:50-1:250

-

酶联免疫吸附实验 (ELISA)

1:10,000

-

免疫沉淀 (IP)

1:50-1:250

-

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide taken within amino acid region 436-486 on Methyl-CpG-binding protein 2 isoform 2 protein.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5-1.5 mg/mL

纯化类型

Affinity chromatography

保存液

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: MeCp-2 protein; MECP2; methyl CpG binding protein 2; Methyl-CpG-binding protein 2; testis tissue sperm-binding protein Li 41a

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基因别名: 1500041B07Rik; AUTSX3; D630021H01Rik; Mbd5; MECP2; MRX16; MRX79; MRXS13; MRXSL; PPMX; RS; RTS; RTT; WBP10

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UniProt ID: (Human) P51608, (Mouse) Q9Z2D6, (Rat) Q00566

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Entrez Gene ID: (Human) 4204, (Mouse) 17257, (Rat) 29386

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four-way junction DNA binding DNA binding transcription factor activity, sequence-specific DNA binding transcription corepressor activity mRNA binding protein binding transcription factor binding methyl-CpG binding double-stranded methylated DNA binding protein domain specific binding chromatin DNA binding siRNA binding histone deacetylase binding poly(A) RNA binding unmethylated CpG binding protein N-terminus binding chromatin binding enzyme binding DNA metabolism protein

negative regulation of transcription from RNA polymerase II promoter behavioral fear response response to hypoxia startle response neurological system process involved in regulation of systemic arterial blood pressure regulation of respiratory gaseous exchange by neurological system process inositol metabolic process mitochondrial electron transport, ubiquinol to cytochrome c chromatin silencing regulation of gene expression by genetic imprinting transcription, DNA-templated glutamine metabolic process cellular biogenic amine metabolic process synapse assembly heart development respiratory gaseous exchange long-term memory locomotory behavior protein localization glucocorticoid metabolic process positive regulation of cell proliferation adult locomotory behavior visual learning response to radiation pathogenesis post-embryonic development response to ionizing radiation response to lead ion dendrite development histone methylation histone acetylation proprioception sensory perception of pain cerebellum development ventricular system development negative regulation of histone methylation cardiolipin metabolic process response to estradiol negative regulation of histone acetylation social behavior neuron maturation negative regulation of neuron apoptotic process regulation of DNA methylation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated phosphatidylcholine metabolic process negative regulation of astrocyte differentiation catecholamine secretion positive regulation of synapse assembly excitatory postsynaptic potential long-term synaptic potentiation regulation of transcription, DNA-templated chemical synaptic transmission brain development learning memory embryo development regulation of gene expression neuron differentiation neuron projection development multicellular organismal response to stress regulation of gene expression, epigenetic regulation of synaptic plasticity neuromuscular process controlling posture neuromuscular process response to organic cyclic compound