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Monoamine Oxidase B Antibody (PA5-18442) in ICC/IF
Immunocytochemistry analysis of Monoamine Oxidase B using Monoamine Oxidase B Polyclonal Antibody (Product # PA5-18442) in paraformaldehyde fixed HeLa cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing nuclear and cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 µg/mL) f... View More
产品信息
PA5-18442
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (HKARKLARLTKEE) corresponding to the internal amino acids of MAOB (aa 347-359).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_10977050
产品详细信息
This antibody is predicted to react with bovine, canine, mouse, porcine and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
靶标信息
MAOB (Monoamine Oxidase B), also called MAO, BRAIN, AMINE OXIDASE (FLAVIN-CONTAINING) B, is a protein that in humans is encoded by the MAOB gene. MAOB is a member of the flavin monoamine oxidase family. And it is mapped on Xp11.3. MAOB catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. Like MAOA, it also degrades dopamine. MAO-B is involved in the breakdown of dopamine, a neurotransmitter implicated in reinforcing and motivating behaviors as well as movement. MAO-B inhibition is, therefore, associated with enhanced activity of dopamine, as well as with decreased production of hydrogen peroxide, a source of reactive oxygen species.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: adrenalin oxidase; Amine oxidase [flavin-containing] B; HGNC:6834; MAO b; MAO, brain; MAO, platelet; MAO-B; MGC26382; Monoamine oxidase type B; RP1-201D17__B.1; tyramine oxidase
基因别名: 6330414K01Rik; MAO-B; MAOB
UniProt ID: (Human) P27338, (Mouse) Q8BW75
Entrez Gene ID: (Human) 4129, (Mouse) 109731
negative regulation of serotonin secretion
neurotransmitter catabolic process
positive regulation of dopamine metabolic process
oxidation-reduction process
response to toxic substance
response to aluminum ion
response to selenium ion
substantia nigra development
response to lipopolysaccharide
dopamine catabolic process
response to drug
response to ethanol
hydrogen peroxide biosynthetic process
response to corticosterone
