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Monoamine Oxidase B Antibody (PA5-29824) in ICC/IF
Immunofluorescence analysis of Amine oxidase [flavin-containing] B was performed using 70% confluent log phase Hep G2 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with Monoamine Oxidase B Polyclonal Antibody (Product # PA5-29824) at 1:100 in 0.1% BS... View More
产品信息
PA5-29824
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein fragment corresponding to a region within amino acids 1 and 176 of Human Monoamine Oxidase B
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2547298
产品详细信息
Recommended positive controls: HepG2, Rat liver.
Predicted reactivity: Human (98%), Mouse (89%), Rat (88%), Dog (94%), Pig (90%), Bovine (90%), Guinea pig (86%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
MAOB (Monoamine Oxidase B), also called MAO, BRAIN, AMINE OXIDASE (FLAVIN-CONTAINING) B, is a protein that in humans is encoded by the MAOB gene. MAOB is a member of the flavin monoamine oxidase family. And it is mapped on Xp11.3. MAOB catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. Like MAOA, it also degrades dopamine. MAO-B is involved in the breakdown of dopamine, a neurotransmitter implicated in reinforcing and motivating behaviors as well as movement. MAO-B inhibition is, therefore, associated with enhanced activity of dopamine, as well as with decreased production of hydrogen peroxide, a source of reactive oxygen species.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: adrenalin oxidase; Amine oxidase [flavin-containing] B; HGNC:6834; MAO b; MAO, brain; MAO, platelet; MAO-B; MGC26382; Monoamine oxidase type B; monoamine oxidase-B; RP1-201D17__B.1; tyramine oxidase
基因别名: 6330414K01Rik; MAO-B; MAOB
UniProt ID: (Human) P27338, (Mouse) Q8BW75, (Rat) P19643
Entrez Gene ID: (Human) 4129, (Mouse) 109731, (Rat) 25750
response to toxic substance
response to aluminum ion
response to selenium ion
negative regulation of serotonin secretion
substantia nigra development
response to lipopolysaccharide
dopamine catabolic process
response to drug
response to ethanol
positive regulation of dopamine metabolic process
hydrogen peroxide biosynthetic process
response to corticosterone
oxidation-reduction process
neurotransmitter catabolic process
response to steroid hormone
