Invitrogen

Munc13-4 Polyclonal Antibody

Munc13-4 Antibody in Immunocytochemistry (ICC/IF)

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Munc13-4 Antibody (PA5-84746) in ICC/IF

Immunofluorecent analysis of Munc13-4 in human cell line U-2 OS using Munc13-4 Polyclonal Antibody (Product # PA5-84746). Staining shows localization to cytosol.

Munc13-4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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产品信息

PA5-84746

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.04-0.4 µg/mL

免疫组化（石蜡） (IHC (P))

1:50-1:200

免疫细胞化学 (ICC/IF)

0.25-2 µg/mL

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human UNC13D. Recombinant protein control fragment (Product #RP-105417).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2791896

产品详细信息

Immunogen sequence: SFHLDMWDLD TVESVRQKLG ELTDLHGLRR IFKEARKDKG QDDFLGNVVL RLQDLRCRED QWYPLEPRTE TYPDRGQCHL QFQLIHKRRA TSASRSQPSY TVHLHLLQQL VSHEVTQHEA GSTSWDGSLS PQAATVLFLH ATQKDLSD

靶标信息

This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.

仅用于科研。不用于诊断过程。未经明确授权不得转售。