Invitrogen

Munc13-4 Polyclonal Antibody

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Munc13-4 Antibody (PA5-89018) in WB

Western blot analysis of Munc13-4 in extracts of various cell lines. Samples were incubated with Munc13-4 Polyclonal antibody (Product # PA5-89018) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.

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产品信息

PA5-89018

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:2,000

酶联免疫吸附实验 (ELISA)

1 µg/mL

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fusion protein containing a sequence corresponding to amino acids 891-1090 of human UNC13D (NP_9547121)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.17 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.01% thimerosal

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2805301

产品详细信息

Immunogen sequence: LIRKYFCSRI QQQAETTSEE LGAVTVKASY RASEQKLRVE LLSASSLLPL DSNGSSDPFV QLTLEPRHEF PELAARETQK HKKDLHPLFD ETFEFLVPAE PCRKAGACLL LTVLDYDTLG ADDLEGEAFL PLREVPGLSG SEEPGEVPQT RLPLTYPAPN GDPILQLLEG RKGDREAQVF VRLRRHRAKQ ASQHALRPAP; Positive Samples: A549, HeLa, HepG2, Mouse lung; Cellular Location: Cytoplasm, Late endosome, Lysosome, Membrane, Peripheral membrane protein, Recycling endosome

靶标信息

This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。