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Product Details
PA5-54070
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human Myotrophin. Recombinant protein control fragment (Product #RP-92642).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2644393
Product Specific Information
Immunogen sequence: NGDLDEVKDY VAKGEDVNRT LEGGRKPLHY AADCGQLEIL EFLLLKGADI NAPDKHHITP LLSAVYEGHV SCVKLLLSKG ADKTVKGPDG LTAFEATDNQ AIKALLQ
Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.
Target Information
The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6. 4 kDa tumor antigen that is associated with myeloproliferative disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Granule cell differentiation protein; growth factor; Myotrophin; Protein V-1; stimulates myocyte growth; V-1 protein
Gene Aliases: 5033418D15Rik; GCDP; MTPN; V-1; V1
UniProt ID: (Human) P58546, (Rat) P62775, (Mouse) P62774
Entrez Gene ID: (Human) 136319, (Rat) 79215, (Mouse) 14489
catecholamine metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cardiac muscle hypertrophy
cell growth
cerebellar granule cell differentiation
neuron differentiation
positive regulation of cell growth
skeletal muscle tissue regeneration
positive regulation of NF-kappaB transcription factor activity
striated muscle cell differentiation
positive regulation of protein metabolic process
regulation of barbed-end actin filament capping
regulation of translation
regulation of striated muscle tissue development
cellular response to mechanical stimulus
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