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N-sulfated Heparan Sulfate Antibody (MA5-46186) in Flow
Flow Cytometry analysis of N-sulfated Heparan Sulfate using N-sulfated Heparan Sulfate Monoclonal Antibody (HepSS-1), Biotin (Product # MA5-46186). Separation of HUVEC cells (red-filled) from SP2 cells (black-dashed) in flow cytometry analysis (surface staining) stained using Anti-N-sulfated heparan sulfate (HepSS-1) biotin antibody (concentration in sample 12 μg/mL, Streptavidin APC).
产品信息
MA5-46186
应用
建议稀释比
已发表文章
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgM
分类
Monoclonal
类型
Antibody
克隆号
HepSS-1
抗原
MethA murine fibrosarcoma
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Size-exclusion chromatography
保存液
TBS, pH 8
内含物
15mM sodium azide
保存条件
4° C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2937579
产品详细信息
This antibody recognizes N-sulfated heparan sulfate (extracellular antigen) present in many species.
靶标信息
Heparan sulfate (HS) is a glycosaminoglycan that is ubiquitously expressed on cell surfaces and in the extracellular matrix and basement membrane. Each HS molecule is a linear polysaccharide composed of repeating disaccharides of hexuronic acid and d-glucosamine that can exhibit immense structural diversity due to substitution to varying extents with sulfate groups and epimerization of glucuronic acid to iduronic acid, with areas of high sulfation and glucuronic acid epimerization being co-located in hot spots throughout the molecule. HS is structurally related to heparin, an extremely highly sulfated form of HS that is restricted to mast cells. The biosynthesis and modification of HS chains is thought to take place within the endoplasmic reticulum, Golgi apparatus, and trans Golgi network, which in the end produce unique HS chains that are covalently attached to a range of core proteins to form HS-proteoglycans [PMID: 24391644].
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Heparan sulfate
