Invitrogen

NADE Polyclonal Antibody

NADE Antibody in Immunohistochemistry (IHC)

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NADE Antibody (PA5-20076) in IHC

Immunohistochemistry of NADE in human brain tissue with NADE Polyclonal Antibody (Product # PA5-20076) at 2 µg/mL.

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产品信息

PA5-20076

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1 µg/mL

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免疫组化 (IHC)

2 µg/mL

产品规格

种属反应

Human, Mouse

已发表种属

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A peptide corresponding to 14 amino acids near the middle of human NADE.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Ion-exchange chromatography

保存液

PBS

内含物

0.02% sodium azide

保存条件

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

运输条件

Ambient (domestic); Wet ice (international)

AB_11152648

产品详细信息

Despite its predicted molecular weight, NADE often migrates at ~23kDa in SDS-PAGE. A suggested positive control is human brain tissue lysate.

PA5-20076 can be used with blocking peptide PEP-0194.

靶标信息

May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death. May play an important role in the pathogenesis of neurogenetic diseases.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Saikosaponin-d impedes hippocampal neurogenesis and causes cognitive deficits by inhibiting the survival of neural stem/progenitor cells via neurotrophin receptor signaling in mice.

Clinical and translational medicine

Qin T,Yuan Z,Yu J,Fu X,Deng X,Fu Q,Ma Z,Ma S

PA5-20076 was used in Western blot to indicate that saikosaponin-d caused hippocampus-dependent cognitive deficits and inhibited hippocampal neurogenesis by reducing the numbers of newborn neurons in mice.

Tue Dec 01 00:00:00 UTC 2020

Saikosaponin-d impedes hippocampal neurogenesis and causes cognitive deficits by inhibiting the survival of neural stem/progenitor cells via neurotrophin receptor signaling in mice.

Clinical and translational medicine

Qin T,Yuan Z,Yu J,Fu X,Deng X,Fu Q,Ma Z,Ma S

Tue Dec 01 00:00:00 UTC 2020

生物信息学

蛋白别名: brain expressed X-linked 3; Brain-expressed X-linked protein 3; Brain-expressed X-linked protein 3 homolog; granule cell antiserum positive 27; nerve growth factor receptor (TNFRSF16) associated protein 1; Nerve growth factor receptor-associated protein 1; Ovarian granulosa cell 13.0 kDa protein HGR74; p75NTR-associated Cell Death Executor; Protein BEX3; RP13-349O20.1

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基因别名: AL033356; Bex; BEX3; DXS6984E; DXWsu67e; Gcap27; HGR74; NADE; NGFRAP1

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UniProt ID: (Human) Q00994, (Mouse) Q9WTZ9

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Entrez Gene ID: (Human) 27018, (Mouse) 12070

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功能

nerve growth factor receptor binding protein binding cysteine-type endopeptidase activator activity involved in apoptotic process metal ion binding death receptor binding

参与通路

activation of cysteine-type endopeptidase activity involved in apoptotic process multicellular organism development extrinsic apoptotic signaling pathway via death domain receptors negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity involved in apoptotic process apoptotic process