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NALCN/VGCNL1 (extracellular) Antibody (ASC-022-200UL) in ICC/IF
Expression of NALCN in rat PC12 cells - Cell surface detection of NALCN in intact living rat pheochromocytoma PC12 cells. Extracellular staining of cells using Anti-NALCN/VGCNL1 (extracellular) Antibody (#ASC-022), (1:50) followed by goat Anti-rabbit-AlexaFluor-594secondary Antibody . Merged image of extracellular staining with live image of the cells.
产品信息
ASC-022-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)SMMFESPFRRVMH, corresponding to amino acid residues 902-914 of rat NALCN, Extracellular, S1-S2 domain III.
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Nalcn is a voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Nalcn regulates the resting membrane potential and controls neuronal excitability (PubMed:17448995). Neuropeptides such as neurotensin and substance P (SP) stimulate the firing of action potentials by activating NALCN through a SRC family kinases-dependent pathway. In addition to its baseline activity, Nalcn activity is enhanced/modulated by several GPCRs, is required for normal respiratory rhythm and neonatal survival, is involved in systemic osmoregulation by controlling the serum sodium concentration. Nalcn is partly responsible for the substance P-induced depolarization and regulation of the intestinal pace-making activity in the interstitial cells of Cajal. Further, Nalcn plays a critical role in both maintenance of spontaneous firing of substantia nigra pars reticulata (SNr) neurons and physiological modulation of SNr neuron excitability. Diseases associated with NALCN include Congenital contractures of the limbs and face, Hypotonia, Developmental Delay and Hypotonia, Infantile Psychomotor Retardation And Characteristic Facies 1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: brain voltage-gated cation channel; CanIon; FLJ23913; FLJ44659; FLJ44764; four domain-type voltage-gated ion channel alpha-1 subunit; four repeat voltage-gated ion channel; MGC74524; Sodium leak channel NALCN; Sodium leak channel non-selective protein; sodium leak channel, non selective; voltage gated channel like 1; Voltage gated channel-like protein 1
基因别名: A530023G15Rik; AI849508; bA430M15.1; CanIon; CLIFAHDD; IHPRF; IHPRF1; INNFD; NALCN; VGCNL1
UniProt ID: (Human) Q8IZF0, (Mouse) Q8BXR5
Entrez Gene ID: (Human) 259232, (Mouse) 338370, (Rat) 266760
calcium ion transport
ion transmembrane transport
regulation of ion transmembrane transport
sodium ion transmembrane transport
regulation of resting membrane potential
calcium ion transmembrane transport
potassium ion transmembrane transport
membrane depolarization during action potential
transport
ion transport
sodium ion transport
transmembrane transport
calcium ion import
sperm motility
cation transmembrane transport
