Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 1
NALP10 Antibody (MA5-24260) in WB
Western blot analysis of NALP10 in Jurkat human acute T cell leukemia cell line, HT‚2 mouse T cell line, and L6 rat myoblast cell line. Samples were incubated in NALP10 monoclonal antibody (Product # MA5-24260) using a dilution of 0.5 µg/mL followed by a HRP-conjugated Anti-Mouse IgG secondary antibody. A specific band was detected for NLRP10/Pynod/NALP10 at approximately 80 kDa (as indicated). This experiment was conducted under reducing conditions.
产品信息
MA5-24260
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
578502
抗原
E. coli-derived recombinant human NLRP10/Pynod/NALP10 Met386-Ile655
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2606974
产品详细信息
In direct ELISAs, no cross-reactivity with recombinant human (rh) NALP1 (aa 1-323), rhNALP1 (aa 1331-1429), rhNALP2 (aa 1-208), rhNALP3 (aa 3-223), rhNALP3 (aa 540-689), rhNALP5 (aa 469-635), rhNOD1 (aa 830-953), or rhNOD2 (aa 230-450) is observed.
Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.
靶标信息
NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP10 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It was initially identified as PYNOD, an Apaf-1-like protein that binds to ASC, caspase-1 and IL-1-b, inhibiting the autoprocessing of caspase-1, caspase-1-mediated IL-1-b processing, and ASC aggregation. NALP10 is thus a potent regulator of apoptosis and inflammation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: NACHT, leucine rich repeat and PYD containing 10; NACHT, LRR and PYD containing protein 10; NACHT, LRR and PYD domains-containing protein 10; NACHT/LRR/pyrin domain-containing protein 10; neuronal apoptosis inhibitor protein 10; NLR family, pyrin domain containing 10; Nucleotide-binding oligomerization domain protein 8; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10
基因别名: 6430548I20Rik; CLR11.1; NALP10; Napl10; NLRP10; NOD8; PAN5; PYNOD
UniProt ID: (Human) Q86W26, (Mouse) Q8CCN1
Entrez Gene ID: (Human) 338322, (Rat) 293426, (Mouse) 244202
positive regulation of T-helper 1 type immune response
helper T cell enhancement of adaptive immune response
dendritic cell migration
defense response to Gram-negative bacterium
defense response to fungus
positive regulation of T-helper 17 type immune response
positive regulation of interleukin-8 secretion
positive regulation of interleukin-6 secretion
adaptive immune response
innate immune response
immune system process
defense response
