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产品信息
PA5-60185
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2644451
产品详细信息
Immunogen sequence: LKRCRSAQVL HLYGATYSAD GEDRARCSAG AHTLLVQLPE RTVLLDAYSE HLAAALCTNP NLIELSLYRN ALGS
Highest antigen sequence identity to the following orthologs: Mouse - 54%, Rat - 53%.
靶标信息
NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kappa-B activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: monarch 1; Monarch-1; NACHT, LRR and PYD domains-containing protein 12; NLR family, pyrin domain containing 12; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12; PYRIN-containing APAF1-like protein 7; Regulated by nitric oxide
基因别名: CLR19.3; FCAS2; NALP12; NLRP12; PAN6; PYPAF7; RNO; RNO2
UniProt ID: (Human) P59046
Entrez Gene ID: (Human) 91662
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
release of cytoplasmic sequestered NF-kappaB
negative regulation of signal transduction
negative regulation of protein autophosphorylation
negative regulation of NF-kappaB transcription factor activity
dendritic cell migration
regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of MHC class I biosynthetic process
regulation of interleukin-18 biosynthetic process
negative regulation of interleukin-6 biosynthetic process
negative regulation of Toll signaling pathway
negative regulation of cytokine secretion
negative regulation of interleukin-1 secretion
positive regulation of interleukin-1 beta secretion
negative regulation of inflammatory response
positive regulation of inflammatory response
negative regulation of ERK1 and ERK2 cascade
cellular response to cytokine stimulus
negative regulation of NIK/NF-kappaB signaling
