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NALP12 Antibody (PA5-89879) in WB
Western blot analysis of NALP12 in extracts of Rat spleen. Samples were incubated with NALP12 Polyclonal antibody (Product # PA5-89879) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
PA5-89879
产品规格
种属反应
Human,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 862-1061 of human NLRP12 (NP_6532881)
偶联物
形式
Liquid
浓度
1.07 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2805820
产品详细信息
Positive Samples: Rat spleen; Cellular Location: Cytoplasm
Immunogen sequence: WLKICRLTAA ACDELASTLS VNQSLRELDL SLNELGDLGV LLLCEGLRHP TCKLQTLRLG ICRLGSAACE GLSVVLQANH NLRELDLSFN DLGDWGLWLL AEGLQHPACR LQKLWLDSCG LTAKACENLY FTLGINQTLT DLYLTNNALG DTGVRLLCKR LSHPGCKLRV LWLFGMDLNK MTHSRLAALR VTKPYLDIGC
靶标信息
NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kappa-B activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: monarch 1; Monarch-1; NACHT, leucine rich repeat and PYD containing 12; NACHT, LRR and PYD domains-containing protein 12; NLR family, pyrin domain containing 12; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12; PYRIN-containing APAF1-like protein 7; Regulated by nitric oxide
基因别名: CLR19.3; FCAS2; NALP12; NLRP12; PAN6; PYPAF7; RNO; RNO2
UniProt ID: (Human) P59046
Entrez Gene ID: (Human) 91662, (Rat) 292541
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
release of cytoplasmic sequestered NF-kappaB
negative regulation of signal transduction
negative regulation of protein autophosphorylation
negative regulation of NF-kappaB transcription factor activity
dendritic cell migration
regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of MHC class I biosynthetic process
regulation of interleukin-18 biosynthetic process
negative regulation of interleukin-6 biosynthetic process
negative regulation of Toll signaling pathway
negative regulation of cytokine secretion
negative regulation of interleukin-1 secretion
positive regulation of interleukin-1 beta secretion
negative regulation of inflammatory response
positive regulation of inflammatory response
negative regulation of ERK1 and ERK2 cascade
cellular response to cytokine stimulus
negative regulation of NIK/NF-kappaB signaling
