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NBL1 Antibody (H00004681-D01P) in WB
Western Blot analysis of NBL1 expression in transfected 293T cell line (H00004681-T01) by NBL1 MaxPab polyclonal antibody.
Lane 1: NBL1 transfected lysate(19.30 KDa).
Lane 2: Non-transfected lysate.
Lane 1: NBL1 transfected lysate(19.30 KDa).
Lane 2: Non-transfected lysate.
产品信息
H00004681-D01P
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
NBL1 (NP_005371.1, 1 a.a. approximately 180 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MLRVLVGAVL PAMLLAAPPP INKLALFPDK SAWCEAKNIT QIVGHSGCEA KSIQNRACLG QCFSYSVPNT FPQSTESLVH CDSCMPAQSM WEIVTLECPG HEEVPRVDKL VEKILHCSCQ ACGKEPSHEG LSVYVQGEDG PGSQPGTHPH PHPHPHPGGQ TPEPEDPPGA PHTEEEGAED
靶标信息
This gene product is the founding member of the evolutionarily conserved CAN family of proteins, which contain a domain resembling the CTCK motif found in a number of signaling molecules. These proteins are secreted, and act as BMP antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DAN domain family member 1; differential screening-selected gene aberrant in neuroblastoma; N03; neuroblastoma candidate region, suppression of tumorigenicity 1; Neuroblastoma suppressor of tumorigenicity 1; Protein N03; Zinc finger protein DAN
基因别名: D1S1733E; D4H1S1733E; DAN; Dana; DAND1; NB; NBL1; NO3
UniProt ID: (Human) P41271, (Mouse) Q61477
Entrez Gene ID: (Human) 4681, (Mouse) 17965
nervous system development
negative regulation of BMP signaling pathway
sequestering of BMP in extracellular matrix
sequestering of BMP from receptor via BMP binding
positive regulation of neuron differentiation
determination of dorsal identity
neuron projection morphogenesis
negative regulation of monocyte chemotaxis
