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产品信息
PA5-101110
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human NBL1(Accession P41271), corresponding to amino acid residues P142-D181.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2850554
产品详细信息
Antibody detects endogenous levels of total NBL1.
靶标信息
This gene product is the founding member of the evolutionarily conserved CAN family of proteins, which contain a domain resembling the CTCK motif found in a number of signaling molecules. These proteins are secreted, and act as BMP antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DAN domain family member 1; differential screening-selected gene aberrant in neuroblastoma; N03; neuroblastoma candidate region, suppression of tumorigenicity 1; Neuroblastoma suppressor of tumorigenicity 1; Neuroblastoma, suppression of tumorigenicity 1 (DNA segment human D1S1733E); Protein N03; Zinc finger protein DAN
基因别名: D1S1733E; DAN; DAND1; NB; NBL1; NO3
UniProt ID: (Human) P41271, (Rat) Q06880
Entrez Gene ID: (Human) 4681, (Rat) 50594
nervous system development
negative regulation of BMP signaling pathway
sequestering of BMP in extracellular matrix
sequestering of BMP from receptor via BMP binding
positive regulation of neuron differentiation
determination of dorsal identity
neuron projection morphogenesis
negative regulation of monocyte chemotaxis
