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产品信息
PA5-47972
产品规格
种属反应
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Mouse myeloma cell line NS0-derived recombinant human DAN Ala17-Asp180 (Ala36Arg)
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2608812
产品详细信息
In direct ELISAs, approximately 25% cross-reactivity with recombinant mouse (rm) DAN is observed and less than 1% cross-reactivity with recombinant chicken Caronte, rmGremlin, and recombinant human Cerberus 1 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
This gene product is the founding member of the evolutionarily conserved CAN family of proteins, which contain a domain resembling the CTCK motif found in a number of signaling molecules. These proteins are secreted, and act as BMP antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DAN domain family member 1; differential screening-selected gene aberrant in neuroblastoma; neuroblastoma candidate region, suppression of tumorigenicity 1; Neuroblastoma suppressor of tumorigenicity 1; Protein N03; Zinc finger protein DAN
基因别名: D1S1733E; DAN; DAND1; NB; NBL1; NO3
UniProt ID: (Human) P41271
Entrez Gene ID: (Human) 4681
nervous system development
negative regulation of BMP signaling pathway
sequestering of BMP in extracellular matrix
sequestering of BMP from receptor via BMP binding
positive regulation of neuron differentiation
determination of dorsal identity
neuron projection morphogenesis
negative regulation of monocyte chemotaxis
