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产品信息
PA5-29232
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 53 and 333 of Human NCK1
偶联物
形式
Liquid
浓度
0.78 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2546708
产品详细信息
Recommended positive controls: K562.
Predicted reactivity: Mouse (98%), Rat (99%), Xenopus laevis (84%), Pig (97%), Sheep (98%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
NCK1 is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Cytoplasmic protein NCK1; melanoma NCK protein; MGC12668; NCK adapter protein 1; NCK tyrosine kinase; Nck-1; non-catalytic region of tyrosine kinase; SH2/SH3 adapter protein NCK-alpha; SH2/SH3 adapter protein NCK1; SH2/SH3 adaptor protein NCK-alpha
基因别名: NCK; nck-1; NCK1; NCKalpha
UniProt ID: (Human) P16333
Entrez Gene ID: (Human) 4690
protein kinase inhibitor activity
SH3/SH2 adaptor activity
ARF guanyl-nucleotide exchange factor activity
receptor binding
protein binding
cytoskeletal adaptor activity
protein domain specific binding
receptor signaling complex scaffold activity
protein binding, bridging
receptor tyrosine kinase binding
eukaryotic initiation factor eIF2 binding
cadherin binding involved in cell-cell adhesion
scaffold/adaptor protein
negative regulation of protein kinase activity
substrate-dependent cell migration, cell extension
actin filament organization
signal complex assembly
vesicle-mediated transport
lamellipodium assembly
positive regulation of actin filament polymerization
negative regulation of peptidyl-serine phosphorylation
positive regulation of translation in response to endoplasmic reticulum stress
Fc-gamma receptor signaling pathway involved in phagocytosis
positive regulation of T cell proliferation
T cell activation
positive regulation of GTPase activity
positive regulation of transcription from RNA polymerase II promoter
vascular endothelial growth factor receptor signaling pathway
T cell receptor signaling pathway
response to other organism
negative regulation of cell death
peptidyl-serine dephosphorylation
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of cap-dependent translational initiation
positive regulation of cap-independent translational initiation
negative regulation of PERK-mediated unfolded protein response
negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
