Invitrogen

NCK1 Monoclonal Antibody (K.349.1)

高级验证
查看其他11个NCK1抗体
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说明书
实验方案
技术支持

产品信息

MA5-15024

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000-1:5,000
-

免疫沉淀 (IP)

1:50
-
产品规格

种属反应

Human, Mouse, Non-human primate, Rat

宿主/亚型

Rabbit / IgG

分类

Monoclonal

类型

Antibody

克隆号

K.349.1

抗原

Synthetic peptide corresponding to residues surrounding Gly300 of human NCK1
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

282 µg/mL

纯化类型

Affinity chromatography

保存液

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

内含物

<0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

RRID

AB_10982803

产品详细信息

It is not recommended to aliquot this antibody.

靶标信息

NCK1 is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Cytoplasmic protein NCK1; melanoma NCK protein; MGC12668; NCK adaptor protein 1; NCK tyrosine kinase; Nck-1; non-catalytic region of tyrosine kinase; non-catalytic region of tyrosine kinase adaptor protein 1; SH2/SH3 adaptor protein NCK-alpha

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基因别名: 6330586M15Rik; D230010O13Rik; NCK; Nck-1; NCK1; NCKalpha

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UniProt ID: (Human) P16333, (Mouse) Q99M51

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Entrez Gene ID: (Human) 4690, (Rat) 300955, (Mouse) 17973

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功能
protein kinase inhibitor activity SH3/SH2 adaptor activity ARF guanyl-nucleotide exchange factor activity receptor binding protein binding cytoskeletal adaptor activity protein domain specific binding receptor signaling complex scaffold activity protein binding, bridging receptor tyrosine kinase binding eukaryotic initiation factor eIF2 binding cadherin binding involved in cell-cell adhesion protein kinase regulator activity
参与通路
negative regulation of protein kinase activity substrate-dependent cell migration, cell extension actin filament organization cell migration lamellipodium assembly positive regulation of actin filament polymerization positive regulation of translation in response to stress negative regulation of peptidyl-serine phosphorylation positive regulation of T cell proliferation T cell activation positive regulation of transcription from RNA polymerase II promoter response to other organism negative regulation of cell death regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation peptidyl-serine dephosphorylation negative regulation of endoplasmic reticulum unfolded protein response positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of cap-dependent translational initiation positive regulation of cap-independent translational initiation negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress signal complex assembly vesicle-mediated transport positive regulation of translation in response to endoplasmic reticulum stress Fc-gamma receptor signaling pathway involved in phagocytosis positive regulation of GTPase activity vascular endothelial growth factor receptor signaling pathway T cell receptor signaling pathway negative regulation of PERK-mediated unfolded protein response negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation regulation of translation
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