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产品信息
PA5-58813
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2644516
产品详细信息
Immunogen sequence: VLIRMYNIKK TCSDPKSKPP FLLEKSMEPS LKYINKKFPN IDVRNSTQHL GPVHREKAEI IRFLTNYYQS FVD
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 97%.
靶标信息
This gene encodes a member of the HEM family of tissue-specific transmembrane proteins which are highly conserved from invertebrates through mammals. This gene is only expressed in hematopoietic cells. The encoded protein is a part of the Scar/WAVE complex which plays an important role in regulating cell shape in both metazoans and plants. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010].
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Hematopoietic protein 1; Membrane-associated protein HEM-1; Nck-associated protein 1-like
基因别名: HEM1; NCKAP1L
UniProt ID: (Human) P55160
Entrez Gene ID: (Human) 3071
B cell homeostasis
myeloid cell homeostasis
protein complex assembly
chemotaxis
maintenance of cell polarity
neutrophil chemotaxis
positive regulation of actin filament polymerization
cortical actin cytoskeleton organization
positive regulation of B cell proliferation
activation of protein kinase activity
negative regulation of interleukin-17 production
negative regulation of interleukin-6 production
positive regulation of cell adhesion mediated by integrin
negative regulation of myosin-light-chain-phosphatase activity
Fc-gamma receptor signaling pathway involved in phagocytosis
positive regulation of T cell proliferation
positive regulation of phosphorylation
response to drug
T cell homeostasis
negative regulation of apoptotic process
positive regulation of CD4-positive, alpha-beta T cell differentiation
positive regulation of CD8-positive, alpha-beta T cell differentiation
positive regulation of GTPase activity
positive regulation of B cell differentiation
positive regulation of gamma-delta T cell differentiation
positive regulation of lymphocyte differentiation
positive regulation of erythrocyte differentiation
vascular endothelial growth factor receptor signaling pathway
erythrocyte development
B cell receptor signaling pathway
positive regulation of phagocytosis, engulfment
actin polymerization-dependent cell motility
positive regulation of neutrophil chemotaxis
