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NCoR1 Antibody (MA5-44982) in IHC (P)
Immunohistochemistry analysis of Nuclear Receptor Corepressor in paraffin-embedded human breast carcinoma tissue. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 2 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with Nuclear Receptor Corepressor Monoclonal antibody (Product # ... View More
产品信息
MA5-44982
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
A6H12
抗原
Recombinant protein within human Nuclear Receptor Corepressor aa 251-450.
偶联物
形式
Liquid
浓度
2 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4, with 40% glycerol, 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2931438
靶标信息
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: h KIAA1047; hCIT529I10; MGC104216; N-CoR; N-Cor/SMRT corepressor Rip13; N-Cor/SMRT corepressor, Rip13; N-CoR1; NCoR; nuclear receptor corepressor; Nuclear receptor corepressor 1; protein phosphatase 1, regulatory subunit 109; retinoid X receptor interacting protein 13; retinoid X receptor-interacting protein 13; thyroid hormone- and retinoic acid receptor-associated corepressor 1
基因别名: 5730405M06Rik; A230020K14Rik; hN-CoR; KIAA1047; mKIAA1047; N-CoR; N-CoR1; NCOR1; PPP1R109; RIP13; Rxrip13; TRAC1
UniProt ID: (Human) O75376
Entrez Gene ID: (Human) 9611, (Rat) 54299, (Mouse) 20185
RNA polymerase II regulatory region DNA binding
RNA polymerase II activating transcription factor binding
chromatin binding
transcription corepressor activity
protein binding
ligand-dependent nuclear receptor binding
protein domain specific binding
estrogen receptor binding
nuclear hormone receptor binding
histone deacetylase binding
peroxisome proliferator activated receptor binding
transcription regulatory region DNA binding
retinoid X receptor binding
thyroid hormone receptor binding
DNA binding
transcription factor activity, sequence-specific DNA binding
histone deacetylase regulator activity
retinoic acid receptor binding
sequence-specific DNA binding
chromatin/chromatin-binding, or -regulatory protein
negative regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
skeletal muscle tissue development
lactation
circadian rhythm
positive regulation of cell proliferation
covalent chromatin modification
cerebellum development
cellular lipid metabolic process
negative regulation of JNK cascade
spindle assembly
regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter
regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
negative regulation of production of miRNAs involved in gene silencing by miRNA
regulation of fatty acid transport
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
negative regulation of gene expression
negative regulation of phosphatidylinositol 3-kinase signaling
chromatin modification
thalamus development
regulation of histone deacetylation
positive regulation of histone deacetylation
circadian regulation of gene expression
regulation of multicellular organism growth
cholesterol homeostasis
negative regulation of transcription, DNA-templated
regulation of catalytic activity
definitive erythrocyte differentiation
regulation of transcription, DNA-templated
